Traces of bird flu are showing up in cow milk. Here’s what to know – Science News Magazine
							May 1, 2024
							    News that bird flu has been spreading between cows for months    and that fragments of the virus are even showing up in milk on    U.S. grocery store shelves have fueled new worries about the    risk the virus poses to people. Among the questions: Is the    virus, known as highly pathogenic avian influenza H5N1,    adapting to better infect mammals? And can people get bird flu    from drinking that milk?  
    Science News went to the experts to find answers to    those questions. The short answer is that, thanks to milk    pasteurization and the way bird flu viruses spread, the risk to    people remains low. Heres a deeper dive into what you should    know.  
    Probably not in pasteurized milk.  
    On April 23, the U.S. Food and Drug Administration announced    that fragments of the bird flus genetic material had turned up    in grocery store milk. Initial results indicate that about 1 in 5 samples contain    bitsof the viruss RNA,the agency announced    April 25. Samples taken from areas where infected dairy cows    have been found were more likely to test positive for the bird    flu virus than those with no infected herds.  
    That doesnt mean that whole infectious viruses are present,    says Michael Osterholm, director of the Center for Infectious    Disease Research and Policy at the University of Minnesota in    Minneapolis.  
    At first blush, it would surely seem as if it should be a    great concern in terms of human health. However, the good news    is that while the virus is in the milk  the pasteurization    process actually is very effective in killing those virus    particles so that in fact, we dont have to be concerned about    Are we ingesting infective material?  
    Pasteurization raises milk to a high enough temperature to kill    bacteria and viruses. Milk has always had bits of dead bacteria    such as E. coli and Listeria that arent    filtered out, Osterholm says. So its not surprising to find    genetic remains of the flu virus, he says, but that by itself    does not at all suggest a public health concern.  
    H5N1 is an envelope virus. And envelope viruses  ones that    wrap themselves in a blanket borrowed from a host cells    membrane  are just a little bit wimpier than non-envelope    viruses and a little bit easier to inactivate, says Meghan    Davis, an environmental epidemiologist at the Johns Hopkins    Bloomberg School of Public Health. That means that theres    some reassurance that pasteurization ought to be working.      
    Because H5N1 has only recently been found in cattle, no studies    have directly tested milk pasteurizations ability to kill the    virus, the FDA said in a statement April 23. But studies have    shown that egg pasteurization, which is done at lower    temperatures than milk pasteurization, inactivates the virus.  
    For those reasons, government officials stress that pasteurized    milk is safe to drink. But the FDA recommends that people dont    drink raw milk, which has not been pasteurized.  
    Davis says there are many reasons to avoid raw milk and    products made from it. We know that raw milk [can contain]    other infectious diseases and there have been outbreaks linked    to raw milk consumption. So categorically I dont recommend    it.  
    Some goats have also been infected with H5N1, so Davis suggests    avoiding raw goat and sheep milk products, too.  
    Decades of evidence suggest thats not likely, Osterholm    says.We have no evidence that humans have become infected from    influenza A virus via ingestion.  
    Some scavenger mammals have become infected with H5N1 from    eating dead birds. But to get into cells, influenza viruses    need to grab onto receptors, cell surface proteins studded with    certain sugars. In humans, those sugars are different than the    versions in scavengers. People carry the entry portals in their    upper respiratory tract and the eyes. The one person in the    United States who recently caught bird flu worked with cows at    a farm in Texas and was diagnosed with conjunctivitis, an eye    infection.  
    It might even be difficult for people to catch the bird flu    from infected cows, Osterholm says. If you look at the    experience weve had in the past, even with all of the human    contact that occurred with infected flocks [of] turkeys and    chickens over the course of the past several years, weve just    seen an absence of infection in humans. Both the U.S. Centers    for Disease Control and Prevention and World Health    Organization have designated the virus as low risk for humans.  
    The U.S. Department of Agriculture first announced finding a    strain of     bird flu in dairy cattle in Kansas and Texas on March 25    (SN: 4/3/24). Since then, the virus has been found in    dairy cows in eight states. The same version of the virus    infecting cows  called clade 2.3.4.4b  has also been found in poultry    in five states, the USDA said in a federal order. That order    announced mandatory testing for all dairy cows before they can    be moved to another state, and also requires tracing the    previous movements of cows from infected herds. The order will    go into effect on April 29.  
    H5N1 may have jumped into cattle only    once and then spread from cow-to-cow, evolutionary    biologist Michael Worobey of the University of Arizona in    Tucson posted on X (formerly Twitter) after he and colleagues    analyzed 239 bird flu viruses from cattle and other species.    The jump may have happened in late December 2023, months    earlier than thought.  
    These findings are still preliminary and havent been    independently verified by other scientists, Davis cautions. But    they do suggest that bird flu in cattle is probably more    widespread than what weve identified based on the reported    cases on the USDA dashboard. What were looking at is probably    circulation, potentially cow-to-cow, but  we dont yet know    the extent.  
    At the moment we have both concern and reassurance, she says.    Despite the low risk, we have the concern that this particular    H5N1 has had staying power and has been around globally since    2020. It has been in the U.S. since 2022. The virus continues    to cause major outbreaks in birds and has jumped into many    species of mammals. That pattern is different from what was    seen with earlier iterations of H5N1 avian influenza. It would    flash up, wed have cases and then it would die off by the next    year. But thats not what were seeing here.  
    Yes, but cases tend to be fairly mild. H5N1 infections in cows    can cause a drop in appetite and milk    production, abnormal feces, tiredness, fever and other    symptoms.  
    Davis, a former dairy veterinarian, says that vets often get    calls that cows are off feed, meaning the animals arent    eating well or giving as much milk as usual. Those symptoms are    not specific to any particular disease, so cases of H5N1    influenza may easily have been overlooked.  
    Some cows may not have any symptoms. Lung tissue taken from one    cow with no symptoms tested positive for the virus, the USDA    announced April 24.  
    The virus has also been found in cats on dairy farms in Texas    and in Poland, South Korea and France. At least one cat died,    according to the World Organization for Animal Health.  
    For poultry such as chickens and turkeys, the virus can be    deadly, destroying flocks in a matter of days.  
    Possibly, Osterholm says. In our business, we almost sleep    with one eye open, just because on any one given day there    could be a change in the virus from mutation or reassortment.  
    Reassortment happens when flu strains swap part of their    genetic instructions. Reassortment generated the H1N1 flu    strain that caused a pandemic in 2009. In a pig, bits from the        1918 pandemic flu strain combined with pieces from a virus    that was already a mish-mash of a swine flu    virus and an avian flu virus. The resulting virus    eventually infected people (SN: 5/22/09; SN: 2/12/10).    The current H5N1 resulted from the reassortment of avian influenza    viruses from poultry and wild birds.  
    What we are concerned about is adaptation of the virus to    better suit some of the receptors that humans might have, which    is why any transmission out of bird populations into any mammal    is initial cause for concern, Davis says. People working on    dairy farms, those in the dairy production chain and anyone    else who may come into contact with raw milk, cows or poultry    should wear protective equipment to avoid possible infection.    She also advocates for testing farm workers, their families and    others in their communities.  
    Both Davis and Osterholm are concerned about the virus    infecting other food animals.  
    The challenge that I see right now on U.S. farms is a virus    getting into hogs, Osterholm says. Pigs carry receptors    similar to the ones found in both humans and birds, making    swine a hog-heaven for bird flus that have potential to become    a pandemic. Meanwhile, Davis says, if this virus can infect    both cows and goats, sheep are on my suspicion list for another    potential species of concern.  
    H5N1 avian influenza viruses have been found in birds since    1996 and have infected more than 880 people    globally since 1997. In the United States, a poultry worker tested    positive for H5N1 in 2022. The dairy farmworker with    conjunctivitis was only the second person in the United States    with a documented bird flu infection.  
    So far, H5N1 has not developed the ability to spread easily    from person-to-person, which would make it a pandemic-potential    virus. Lightning could strike tomorrow, Osterholm says, but    at least based on the track record so far, theres been very    little evidence to support that this is going to infect humans    [and] then be transmitted by people to other people.  
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Traces of bird flu are showing up in cow milk. Here's what to know - Science News Magazine