SAG-AFTRA Hit With Over 100 Covid Vaccine Mandate Suits By Members; Claims Are Without Merit, Guild Says – Deadline

SAG-AFTRA Hit With Over 100 Covid Vaccine Mandate Suits By Members; Claims Are Without Merit, Guild Says – Deadline

Spread of respiratory illness in dogs prompts free vaccine clinic – KOB 4

Spread of respiratory illness in dogs prompts free vaccine clinic – KOB 4

December 10, 2023

In response to the spread of a respiratory illness in dogs, Bernalillo County officials are hosting a free vaccine clinic next week.

ALBUQUERQUE, N.M. In response to the spread of a respiratory illness in dogs, Bernalillo County officials are hosting a free vaccine clinic next week.

The clinic will take place Wednesday, Dec. 13, from 1-4 p.m. Officials say that while there are no identified positive cases in New Mexico, theyre offering these free Bordetella shots as a proactive precautionary measure.

The walk-up clinic will take place at the resource center, located at 3001 2nd Street SW. Dogs and puppies will receive the Bordetella immunization on a first-come, first-served basis.

The Bordetella immunization is one of several ways to reduce and protect dogs should the Canine Respiratory Syndrome make its way into New Mexico, an official said in a news release. Animals should be vaccinated for at least two weeks before commingling with other animals. That includes areas such as dog parks, groom facilities and boarding centers.

Symptoms of the Canine Respiratory Syndrome include but are not limited to:

Officials say, if your dog displays more than one of those symptoms, you should contact a veterinarian immediately.

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Use of Inactivated Polio Vaccine Among U.S. Adults… – CDC

Use of Inactivated Polio Vaccine Among U.S. Adults… – CDC

December 10, 2023

Polio vaccination has been part of routine childhood immunization since the late 1950s. Adults who received any childhood vaccines almost certainly were vaccinated against polio. Thus, most adults who were born and raised in the United States can assume they were vaccinated against polio as children, even if they do not have written documentation of vaccination, unless they have specific reasons to believe they were not vaccinated. The current definition of a complete primary polio vaccination series is receipt of 3 appropriately spaced doses of tOPV or IPV in any combination, with the final dose in the series administered on or after the fourth birthday.

Adults who might be at increased risk for exposure to poliovirus include travelers to countries where polio is epidemic or endemic, laboratory and health care workers who handle specimens that might contain polioviruses, health care workers or other caregivers who have close contact with patients in a community with a polio outbreak, and other adults who are identified by public health authorities as being part of a group or population at increased risk for exposure to poliovirus because of an outbreak.

Adults requiring a primary polio vaccination series should receive 2 doses of IPV administered at an interval of 48 weeks; a third dose should be administered 612 months after the second dose. There is no need to restart the series if the interval between doses exceeds the recommended interval. If 3 doses of IPV cannot be administered within the recommended interval before protection is needed (e.g., before travel to a country with endemic polio), an accelerated schedule is recommended based on the amount of time available.

IPV is an inactivated vaccine and is safe to administer to persons who are immunocompromised or who have close contact with other persons who are immunocompromised. However, IPV might be less effective when administered during periods of altered immunocompetence. For this reason, when feasible, IPV should be administered before initiation of immunosuppressive therapy or anticipated period of altered immunocompetence. Specifically, for persons anticipated to be eligible for an IPV booster in the future (e.g., before travel to a country with endemic polio), administration of the booster dose before the period of altered immunocompetence should be considered. Additional guidance regarding immunization in persons with specific conditions is available at https://www.cdc.gov/vaccines/hcp/acip-recs/general-recs/immunocompetence.html.

Contraindications and precautions are unchanged from previous recommendations. Severe allergic reaction (e.g., anaphylaxis) to IPV or to antibiotics contained in trace amounts in IPV (streptomycin, polymyxin B, or neomycin) is the only contraindication to administration of IPV. Pregnancy is a precaution to administration of IPV. Although there is no evidence that IPV vaccine causes harm to pregnant persons or their fetuses, out of an abundance of caution IPV should not be given during pregnancy if there is not an increased risk for exposure. However, if a pregnant person is at increased risk for exposure and requires immediate protection against polio, IPV can be administered in accordance with the recommended schedule for adults (2).

Adverse events occurring after administration of any vaccine should be reported to the Vaccine Adverse Event Reporting System (VAERS). Reports can be submitted to VAERS online, by fax, or by mail. Additional information about VAERS is available by telephone (1-800-822-7967) or online at vaers.hhs.gov.


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Use of Inactivated Polio Vaccine Among U.S. Adults... - CDC
Fran Drescher Gets Candid About the SAG Deal, AI, and Vaccine Mandates – Rolling Stone

Fran Drescher Gets Candid About the SAG Deal, AI, and Vaccine Mandates – Rolling Stone

December 10, 2023

Vivien Killilea/IMDb/Getty Images

After four long months marching on Hollywood picket lines, bargaining inside hostile negotiating rooms, and giving Buddhist sermons, Fran Drescher can finally exhale.

Through the 118-day actors strike, The Nanny star turned SAG-AFTRA national president, joined by SAG-AFTRA chief negotiator Duncan Crabtree-Ireland, has served as the face of the 160,000-strong union and says she uses the Nineties sitcoms message around unity and acceptance in her leadership. I can be exactly who I am, she says in her raspy Queens accent, and still rock a red lip and hold a plushie toy.

On Dec. 5, Screen Actors Guild members approved multi-year contracts with the Hollywood studios and streamers, or the Association of Motion Picture and Television Producers (AMPTP), by 78.33 percent, with 21.67 percent dissenting. Lauded as the billion-dollar deal, which will run through June 30, 2026, actors will receive residual and minimum wage increases, along with certain AI protections.

But Drescher has not been free from criticism. Before the strike began in July, she faced backlash for cheesing next to Kim Kardashian during a Dolce & Gabbana promotional trip and following the strikes end on Nov. 8, actors spoke out on the then-tentative deals AI provisions.

Despite this, Drescher felt certain that SAG-AFTRA members would ratify the agreement. During an interview this week following the deals approval, she says the vote and turnout was a sigh of relief. (The vote received a 38.15 percent turnout, compared to the 27.15 percent of members who ratified the TV/theatrical contracts in 2020.)

Even the naysayers will see the benefits of it as they work the contract themselves, Drescher quips.

As Drescher reflects on the months that upended the film and TV industry, she tells Rolling Stone about the Venus and Mars energy in the bargaining room, how Disney CEO Bob Iger ignited the hot labor summer, and the possibility of a book documenting her SAG-AFTRA leadership.

The deal was ratified Tuesday night. How are you feeling? Is this what you anticipated? I dont get a lot of opportunities to rest on my laurels. Its all going to flood over me at a time thats not immediate. In the immediate, Im actually just putting one foot in front of the other and making sure that I represent the union and my position as best as I can so that the communication that goes out to the world is the right one. Its a lot of pressure, but I think I slept better last night than Ive slept in many months because it was over and its done. Now we can experience it, live it, and build upon it.

I want to talk about two major points that led both SAG-AFTRA and the AMPTP to reach a tentative agreement: the streaming bonus and AI protections. What was the last piece that SAG-AFTRA needed from the AMPTP on AI? What we needed was that we get compensation and consent and that they had to tell us in very clear language what they would use it for on a particular job specifically. [It] could only be used for that one job. We went from not having any protections they would be pulling our members off to go get scanned and think that was OK and they could just use it in perpetuity and now weve put it into the members decision. Theyre in the drivers seat now.

As we know, 21.67 percent of members voted against the deal. Justine Bateman has criticized the AI provisions, SAG-AFTRA board member Matthew Modine said consent is surrender, and some actors I spoke to still have concerns. Do you have anything to say to these actors that are still worried about losing their voice and likeness during productions? Even [AMPTP president] Carol Lombardini said that Duncan Crabtree-Ireland she is fully aware is always the smartest one in the room. So dont trust them either and then dont trust your negotiating committee who gave blood, sweat, and tears for a year of their lives sacrificing so much for them, fought so hard to get a billion-dollar deal that was three times bigger than the last contract and bigger than the last three contracts put together. [They] filled page after blank page with new language and recognized for the first time performance capture. For 21 years, theyve been trying to get that into a contract and we got it in.

Some people get very obsessed on one thing and are willing to throw the baby out with the bath water. In two and a half years, were gonna roll up our sleeves and go right back into it but in the meantime, we went from nothing to putting our members in the drivers seat when it comes to AI. The things that have been brought up seem like this is not what you obsess on unless youre an obsessive personality. What I do feel is that the majority of the members understood that this is going to benefit our members in a way that has never been achieved since the 1960 contract, which got us pension, health care, and residuals. That is not something that you walk away from because to walk away from a deal like this makes you look like a fool and not to be taken seriously.

The streaming bonus, whats been nicknamed the Robin Hood fund, gives performers on heavily-watched streaming shows a bonus. I understand 75 percent of the fund will go to actors on those high-budget streaming shows, but who will get the other 25 percent? That hasnt been decided yet. I think that we need to really think about how it will be best used, who will benefit. Obviously, its going to be people that are on that platform. We havent really thought about the best and most fruitful way to distribute that money, but we will and it will be whats most beneficial for the most members.

When the women would cry over an issue that they were passionate about, my heart broke for them. I listened with great empathy, and I wanted to fix it. I wanted to make it better. When the men were very aggressive and fist-pounding, I couldnt even hear that.

I want to talk about the secret sauce you used in the negotiating room: your heart-shaped plushie, Buddhist mantras, and feminine energy. How did these practices help you reach this deal? If someone is angry and fists pounding on the table, and acting like theyre gathering their things because theyre gonna march out any second and whatever it is, shouting, [theres] all of this really aggressive male energy not only in the room, frankly, but in the negotiating committee room. Men generally, in my observations through this experience, react very differently than women. Mostly, all the tears that happened were from women and when the women would cry over an issue that they were passionate about, my heart broke for them. I listened with great empathy, and I wanted to fix it. I wanted to make it better. When the men were very aggressive and fist-pounding, I couldnt even hear that.

When you say men on both sides were shouting and pounding on the table, were you referring to a specific person? Im talking about gender at large. There was nobody specifically that I would say was more physical or more offensive or anything like that. I was just able to passively observe the way the same problem is dealt [with] between men and women, and it has nothing to do with their intellect. There were really smart people in the room, men and women. But, its Venus and Mars, baby.

You questioned if Disney CEO Bob Iger was an ignoramus after he called actors demands unrealistic. How did you feel about comments around the deal being too far or too much for actors? Look, Bob and the rest of them Im sure would be very charming at a cocktail party, but he actually helped ignite the Hot Labor Summer because his comments were so tone-deaf, in the way that they showed the inequity between the highest-paid at the company and our members who are struggling to make a living and get medical benefits. So, it was what he said in contrast to my speech that bookended the whole conversation in a nutshell and triggered the Hot Labor Summer around the world.

In an email chain, you said you were willing to go on strike in 2021 over Hollywoods vaccination mandates. Why is that? I didnt think that vaccine mandates were something that the employers should have imposed on our members. I thought it should be an option. I thought that the original pieces that were put in place for COVID protections were working long before the vaccine was introduced. Those protocols should have remained in place and the vaccine should have been a personal choice. But no matter how many times I brought it to the board as a single-item discussion, no matter how much I presented them with video from doctors that disagreed with the vaccine, or articles that showed how companies were managing differently, the majority of the members on the board voted not to go up against the employer.

I had to get on with the business of being president and solving many, many other problems successfully, I might add but I could not become a one-issue president. There was too much at stake, too much to do, too much to fix, and too much division to the degree of great dysfunction.

With the actors strike behind you, are we going to see you on screen soon? Im supposed to do the sequel to [This is] Spinal Tap. Im also supposed to do another independent film with Ben Affleck and Adam Sandler. That all went on the back burner during the strike. Im sure theyll circle back when the time is right to pick up those little movies. My writing, Ive been neglecting. I feel like theres for sure a book about this whole experience.

I dont know whether Im gonna dive into another sitcom because I like climbing new mountains and something like this that Ive accomplished and being seen through a new lens which didnt surprise any of the people that know me very well but certainly did surprise everybody that only knew me as the Nanny I could see myself doing something where I can apply more of my skills to influencing the way people think in a new and fresh way. Maybe a new 21st-century Fran Drescher-style Barbara Walters.


Excerpt from: Fran Drescher Gets Candid About the SAG Deal, AI, and Vaccine Mandates - Rolling Stone
How effective is the flu vaccine in preventing the disease? – The Jerusalem Post

How effective is the flu vaccine in preventing the disease? – The Jerusalem Post

December 10, 2023

Many people mistakenly believe that the flu is just a mild cold or a winter ailment. However, the Health Ministry emphasizes that influenza is a highly contagious and severe viral disease.

The flu virus spreads through coughing, sneezing, and contact with nasal secretions and phlegm, which contain a multitude of viruses.

The infection rate for flu is alarmingly high. It primarily affects the respiratory tract and results in symptoms such as fever (over 38 degrees Celsius), sore throat, headache, runny nose, cough, muscle pain, weakness, fatigue, and loss of appetite.

Pneumonia is a common complication of the flu, often requiring hospitalization for vulnerable groups such as young children, pregnant women, the elderly, and immunocompromised individuals.

To combat this, the Health Ministryrecommends flu vaccination for everyone over the age of 6 months. The flu vaccines provide effective protection for one winter season.

Each year, a new vaccine formulation is produced containing the four strains of influenza expected to be prevalent in the upcoming year.

To understand the effectiveness of the flu vaccine, let's examine the situation in the UK. The UK is at the forefront of childhood flu vaccination in the Western world and has implemented a systematic program to vaccinate children in schools for several years.

The vaccination takes place before winter using a nasal spray. Numerous studies conducted in the UK have not only shown a high response rate to the vaccine, but also significant effectiveness in reducing the spread of the virus and the risk of hospitalization.

According to the latest report published in July, which assesses the vaccine's effectiveness annually, there was a two-thirds decrease in the risk of hospitalization among children aged 2-17 who were vaccinated against the flu. Most of these children received the nasal spray vaccine.

This year's report, unlike previous seasons, primarily focuses on the dangers of the flu and its potential complications. It examines the vaccine's effectiveness in preventing hospitalizations in children, whereas previous reports analyzed various parameters such as clinic visits or flu-like symptoms.

The UK recognizes that school students are particularly susceptible to the flu and act as major spreaders of the disease in the community. Consequently, the flu vaccination program in schools has been expanded throughout the UK for children aged 4-17.

It's important to note that influenza is a complex disease that undergoes changes each season, presenting three to four different strains every winter. Therefore, revaccination is crucial, even if you or your child have already been exposed to the flu.

Exposure to one strain does not guarantee protection against other strains. Only through vaccination can the body generate natural antibodies against the specific flu strains identified by the World Health Organization as the cause of the disease.

However, it's worth mentioning that vaccine effectiveness typically ranges between 50-75%. In some years, when the estimated vaccine strains do not match the actual flu strains, the effectiveness may fall below 50%. A study conducted during the 2020-2021 flu season in Denmark found high effectiveness (ranging from 66% among children aged 2-6 to 72% among children and adolescents aged 2-17) of the nasal spray vaccine.


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How effective is the flu vaccine in preventing the disease? - The Jerusalem Post
New book by Dr. Peter Hotez takes on the anti-science movement – Texas Public Radio

New book by Dr. Peter Hotez takes on the anti-science movement – Texas Public Radio

December 10, 2023

Get TPR's best stories of the day and a jump start to the weekend with the 321 Newsletter straight to your inbox every day. Sign up for ithere.

One renowned vaccine scientist became a voice of reason during the COVID-19 pandemic. Dr. Peter Hotez is professor and dean of the National School of Tropical Medicine at Baylor College of Medicine in Houston. His new book is called The Deadly Rise of Anti-science: A Scientist's Warning.

On this episode of Weekend Insight, TPRs Jerry Clayton talks to Hotez about some of the experiences that led to the writing of his newest book.

This conversation has been edited for length and clarity

Clayton: During the pandemic, you were attacked by anti-vaxxers, but this is not something new. Tell me about what happened after you wrote the book, Vaccines Did Not Cause Rachel's Autism back in 2019.

Hotez: Yeah, that was my first effort to go up against a rising anti-vaccine lobby here in the United States, which unfortunately is particularly strong in Texas. And it was around false claims that vaccines cause autism. The original assertion was that the measles, mumps, rubella vaccine did it.

That was in a paper that was published in The Lancet, an important medical journal, but it was shown to be false and retracted. And from then on, anti-vaccine groups started monetizing the internet, selling phony autism cures or nutritional supplements that nobody needed or anti-vaccine books on Amazon. So it became its own industry and not even a cottage industry, a multibillion dollar industry in time.

And even though the scientific community refuted the measles, mumps, rubella vaccine, then they said it was the thimerosal preservative that was in vaccine. Robert F. Kennedy Jr. had written an article in Rolling Stone to that effect. That was also shown not to be true. And then it was spacing vaccines too close together.

Or they made up stories about HPV vaccines for cervical cancer and other cancers. So it became kind of this game of whack a mole or moving the goalposts. And that's why I wrote the book to kind of really tamp down the false assertions about vaccines.

Clayton: You famously declined to debate Robert F Kennedy Jr. on Joe Rogan's show. Was that an easy decision for you?

Hotez: Yeah, that was never in the cards. I've known Bobby Kennedy for a number of years and I've had a number of conversations with him over the years. They didn't get anywhere. He's just too dug in, doesn't want to listen to the science. So I knew it wouldn't be productive, but I also thought it could harm the field because it would give people the wrong message about how science works.

I mean, science is not something that's achieved through public debate. Science is achieved through writing scientific papers by serious scientists that submit articles for peer review, and then they get modified or rejected and grants that get modified, rejected, or you present in front of scientific conferences in front of your peers for critical feedback. And it's a very successful approach.

You don't debate science like you'd debate enlightenment, philosophy or politics.

Clayton: This most recent rise in anti-science, is it psychological, do you think, or is it just politics?

Hotez: It's hard to untangle those two, but it's clear that the people who lost their lives, those 40,000 Texans and 200,000 Americans overall were victims.

In my view, they were victims of a predatory, anti-science, anti-vaccine movement that started and this is what I talk about in the book at the CPAC Conference of Conservatives that was held in Dallas in the summer of 2021, where the rhetoric was first, they're going to vaccinate you, then they're going to take away your guns and your Bibles. And as ridiculous as that sounds to us, people in our state of Texas accepted it.

And then the pile on came from leaders of the United States Congress, from the House Freedom Caucus. People like Marjorie Taylor Greene of Georgia called people like me who want to vaccinate medical brownshirts, comparing vaccines to the Holocaust and then were amplified every night on Fox News. Tucker Carlson, Sean Hannity, Laura Ingraham, every night during that horrible Delta wave when so many people in Texas and the United States refused to get vaccinated and died from Covid.

Those nighttime Fox News anchors with 3 million viewers each filled their broadcast with anti-vaccine content and ultimately people paid for it with their lives. And then how do we reverse that trend, I think, is one of the really great, great challenges.


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New book by Dr. Peter Hotez takes on the anti-science movement - Texas Public Radio
New experimental breast cancer vaccine prevents disease from returning – CBS News

New experimental breast cancer vaccine prevents disease from returning – CBS News

December 10, 2023

Watch CBS News

The vaccine works by making the immune system attack any tumor cells to keep them from growing. Results of the first trial were released this week. No one had any bad side effects and none of their cancer returned.

Be the first to know

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New experimental breast cancer vaccine prevents disease from returning - CBS News
World Bank drives Covid-19 recovery in East Asia, Pacific with USD 1.9 billion commitment and vaccination success … – IndiaTimes

World Bank drives Covid-19 recovery in East Asia, Pacific with USD 1.9 billion commitment and vaccination success … – IndiaTimes

December 10, 2023

NEW DELHI: Countries in East Asia and the Pacific (EAP) were among the first and hardest hit by the Covid-19 pandemic. In response, the World Bank swiftly executed a comprehensive strategy, channelling funds into emergency operations, training medical staff, and reinforcing national public health systems. This approach included reallocating existing project resources, triggering emergency components, and activating Catastrophe Deferred Drawdown Options (CAT DDOs) tailored to each country's unique context and epidemic status. The World Bank committed USD 1.9 billion across 18 Covid-19 health response projects in the EAP region from April 2020 to October 2022. Notably, the Philippines received 33 million vaccine doses (13 per cent of the total supply), while Mongolia procured vaccines to inoculate up to 66 per cent of its population with two doses. With World Bank support, the Lao People's Democratic Republic achieved a 76 per cent full vaccination rate, and 94 per cent of Covid-19 testing samples were reported within 48 hours of testing. The EAP region faced significant disruptions, with the World Bank estimating that the Covid-19 shock could push an additional 38 million people into poverty in 2020. The impact on sales, employment, and productivity growth, particularly affecting small and medium enterprises (SMEs), necessitated urgent intervention. The World Bank's response to EAP since April 2020 involved deploying over USD 157 billion globally. In the EAP region, emergency operations through the Covid-19 Fast-Track Facility addressed economic, social, and poverty impacts. The World Bank also repurposed existing projects, utilizing Contingent Emergency Response Components (CERCs) and activating Catastrophe Deferred Drawdown Options (CAT DDOs). Countries in EAP witnessed positive outcomes from the World Bank's initiatives. The bank committed USD 1.93 billion across 18 Covid-19 health response projects, and an additional USD 40.5 million was reallocated through CERCs and CAT DDOs. Noteworthy successes include Indonesia's treatment of 6 million Covid-19 cases and testing 60 million suspected cases, and the Philippines receiving 33 million vaccine doses. Collaborating with various partners such as the Covax initiative, other multilateral development banks, and international agencies, the World Bank formed a broad coalition for a multi-faceted response. Partnerships with the Asian Development Bank (ADB), the Asian Infrastructure and Investment Bank (AIIB), and the World Health Organization (WHO) facilitated project preparation and vaccine financing. The EAP Economic Update in April 2023 indicates economic recovery in major EAP economies, with GDP growth and increased per capita income. The World Bank's Evolution Roadmap prioritizes urgent action to address poverty, economic distress, and global challenges like climate change and pandemics, recognizing the cross-border nature of these issues.


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World Bank drives Covid-19 recovery in East Asia, Pacific with USD 1.9 billion commitment and vaccination success ... - IndiaTimes
Novak Djokovic: People tried to label me as anti-vaccine and I’m for it – Marca

Novak Djokovic: People tried to label me as anti-vaccine and I’m for it – Marca

December 10, 2023

Novak Djokovic is already thinking about next season and his challenge to win the title of the Australian Open, which would put more distance between him and Rafael Nadal in the race for more 'Grand Slam'.

The world number one, in his latest interview for the CBS 60 Minutes programme, spoke of his refusal to be vaccinated against the coronavirus, which caused him to miss many tournaments, and made it clear that "people tried to brand me as anti-vaccine when I'm not. I am in favour of vaccines in the same way that I am in favour of freedom of choice.

Djokovic also spoke about his rivalry with Nadal and Roger Federer, with whom he formed the historic 'Big Three' of the sport: "I have enormous respect for them, that's what I can say. We are not friends because we are rivals and you can't share certain things that could go against you. I would love to be able to have dinner with Rafa and Roger in a while".

The 24-time major champion, who rested for a few days at his home in Marcella at the end of the Davis Cup finals in Malaga, will spend his pre-season in Dubai with his compatriot Hamad Medjedovic, the recent winner of the Next Gen Finals in Jeddah.

He will then travel to Riyadh (Saudi Arabia) to play an exhibition with Carlos Alcaraz on 27 December. It will be a technical stop on his way to Australia. He will play the United Cup in defence of Serbia. The venue for the Balkan team's matches will be Perth.

Djokovic will open on December 31 against China's Zhizhen Zhang.


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Novak Djokovic: People tried to label me as anti-vaccine and I'm for it - Marca
Vaccine for superbugs? New shot shows promise in early tests – Livescience.com

Vaccine for superbugs? New shot shows promise in early tests – Livescience.com

December 10, 2023

Hospitalization is supposed to make people well. But on a given day, an estimated 1 in 31 hospitalized patients contracts an infection from the hospital itself, and tens of thousands die annually. Many of these infections are antibiotic-resistant, and treating them contributes to the evolution of new "superbugs."

But now, researchers have a new idea for preventing hospital-acquired infections: a vaccine that puts the immune system on short-term high alert for a broad array of pathogens.

The vaccine, so far tested only in mice, activates the innate immune system, the body's first line of defense, according to a study published Oct. 4 in the journal Science Translational Medicine. The innate immune system is not specific to any particular pathogen, and its protection tends to fade faster than that of the adaptive immune system, which "remembers" viruses and bacteria it has encountered in the past. (Most vaccines train the adaptive immune system to fight off specific diseases, such as the seasonal flu or COVID-19.)

But for hospitalized patients, broad and short-term protection is needed most, said Brad Spellberg, the senior study author and chief medical officer at the Los Angeles General Medical Center.

"It solves a problem that traditional vaccines have not been able to solve," Spellberg told Live Science.

Related: Dangerous 'superbugs' are a growing threat, and antibiotics can't stop their rise. What can?

There are too many potential hospital-acquired pathogens to reasonably vaccinate incoming patients for each individual bacterium or fungus, Spellberg said. And in any case, traditional vaccines require time to activate adaptive immunity, and hospitalized patients need immediate protection.

The researchers stumbled across the idea for the new vaccine more than 15 years ago while looking to develop a traditional vaccine for Staphylococcus aureus, a common source of hospital infections. Certain strains of the bacterium, known as methicillin-resistant S. aureus (MRSA), are resistant to common antibiotic treatments.

The researchers were struggling to find a combination of bacterial proteins that would protect against staph infections in the blood, so they began adding a series of compounds called adjuvants to their formulation. Adjuvants are ingredients that broadly boost the immune response to a desired target.

Eventually, the researchers found a combination of three bacterial proteins and three adjuvants that worked in animal studies. But during testing, they found that giving mice a vaccine with only the three adjuvants was just as protective as giving them the vaccine with proteins and adjuvants combined.

"We were like, 'Whoa, whoa, whoa, what is going on here?'" Spellberg said.

What was going on, another decade of testing revealed, was that the vaccine was not specifically targeting the staph proteins. Rather, it was boosting the activity of the innate immune system more broadly and that was enough to protect the mice from staph infection.

"It's an important and exciting concept for a vaccine," said Marcela Henao Tamayo, an immunologist at Colorado State University who was not involved in the new study.

The three adjuvants aluminum hydroxide, monophosphoryl lipid A, and fungal mannan protected mice against not only S. aureus but also strains of other common hospital-acquired pathogens with various degrees of antibiotic resistance, such as Enterococcus faecalis, Escherichia coli, Acinetobacter baumannii and Klebsiella pneumoniae. The vaccine also protected against the fungi Rhizopus delemar and Candida albicans, which also frequently affect hospitalized people.

Related: Cleaning product residues may be driving a deadly superbug's antibiotic resistance

Aluminum hydroxide and monophosphoryl lipid A are already used in vaccines and approved by regulatory agencies in both the U.S. and Europe, Spellberg said. Mannan, a component of fungal cell walls, is not yet an approved vaccine adjuvant, but it has been tested in humans in other medications without apparent safety issues, he said.

The research also found that the key reason the adjuvant-only vaccine worked was that it activated macrophages, immune cells that engulf and destroy foreign invaders. The researchers also observed other changes in the immune system, such as an increase in anti-inflammatory immune proteins called cytokines, and a decrease in pro-inflammatory cytokines. Though all the mechanisms aren't clear, this ratio has been linked to better survival after infection in previous studies, the researchers wrote.

In mice, the vaccine's protection persisted for 28 days.

Giving this vaccine to patients upon hospitalization or before outpatient surgery could reduce the rate of hospital-borne infections and help combat the problem of antibiotic resistance, study co-author Jun Yan, a doctoral student in microbiology at the University of Southern California.

"By reducing the infection rate in the hospital, we're also reducing the new emergence of antibiotic resistance, because we can also reduce the use of antibiotics in hospitals," Yan told Live Science.

Human testing is the next step. Other vaccines, such as the live tuberculosis vaccine, have long been known to trigger an innate immune response in addition to raising the body's guard against specific germs, Henao Tamayo, who studies those vaccines, told Live Science. But getting a nonspecific vaccine approved by the Food and Drug Administration (FDA) is new territory, Spellberg said. The research team is currently in talks with the FDA about what kind of testing would be needed, and they hope to begin clinical trials in 12 to 18 months.

"I think what they have already developed is highly promising," Henao Tamayo said, "and we could learn a lot from human studies."


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Vaccine for superbugs? New shot shows promise in early tests - Livescience.com
Boris Johnson considered raid on vaccine plant in the Netherlands – The Guardian

Boris Johnson considered raid on vaccine plant in the Netherlands – The Guardian

December 10, 2023

Boris Johnson

Covid inquiry expected to be told former PM was open to military options to obtain impounded jabs from factory in Leiden

Boris Johnsons appearance before the Covid-19 inquiry is not until Wednesday but it is already making headlines in the Netherlands amid a mixture of amusement and alarm at claims he asked for British spies to plan a raid on a Dutch vaccine plant.

The operation according to sources who briefed Johnsons employer, the Daily Mail would have taken place against the backdrop of a tit-for-tat row in March 2021 between the then prime minister and the EU, which was moving towards restricting exports of vaccines across the Channel.

An enraged Johnson asked security services to draw up military options to obtain impounded doses of AstraZeneca vaccine from a plant in Leiden after Britain had negotiated a deal with the company.

But while Britains security services were spared their biggest debacle on Dutch soil since Operation Market Garden, the claim has been widely reported on front pages in the Netherlands. Elsewhere, Russian state media generated a po-faced report on the claims, interspersing clips of Johnson with footage of British special forces and overlaying them with a sinister backing track.

The Dutch ministry of foreign affairs confirmed it was aware of the report but declined to comment.

Johnson is expected to refer to the episode, potentially in a written statement accompanying his evidence to the inquiry, which will take place over the course of Wednesday and Thursday.

Figures close to Johnson have been busily briefing the media before his appearance, advising that he will reject claims that he was not sufficiently engaged in policy during the 10-day period.

The former Conservative leader will reject claims that he did not concentrate on the looming threat of the pandemic during the half-term break in February 2020 because he was supposedly writing a biography about William Shakespeare.

A spokesperson for Johnson previously rejected reports that he was focused on the book during the critical period in question but Downing Street also did not deny that Johnson had worked on the book, for which he received a 88,000 advance from his publisher Hodder & Stoughton UK in 2015, since becoming prime minister in July 2019.

The evidence shows, from the diary extracts, that he wasnt away all the time. He came back into the office from Chevening. The records show he was working the whole time, he wasnt writing a book We think this one is quite easily dealt with. the Telegraph quoted a source close to Johnson as saying.

Johnson is expected to admit some fault when he is cross examined at the inquiry but will also seek to talk up the things that he believed he got right, ranging from the vaccines rollout to eventually opening up the economy.

He will argue that those criticising him have been doing so from specific perspectives including science, the economy and broader public health and that he was the only person who had to balance all of these things.

The former prime minister will resist going on the attack, according to his supporters, and will also seek to offer ideas about how the UK could cope with a future pandemic.

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More here: Boris Johnson considered raid on vaccine plant in the Netherlands - The Guardian