Del Sol Medical Center's Chief of Medicine Doctor Fahad Omar. October 26, 2023. Credit: KFOX14/CBS4
EL PASO, Texas (KFOX14/CBS4)
As part of October's Healthy Lung Month, an El Paso doctor wants to remind the borderland how to stay healthy as the seasons change.
Del Sol Medical Center's Chief of Medicine Doctor Fahad Omar spoke with KFOX14/CBS4 on how to keep lungs healthy and how to look out for warning signs, such as runny nose or fatigue.
"I think one of the most important things in the upcoming months, needs to be that patients need to be vaccinated," Doctor Omar said.
Doctor Omar said people tend to feel sick a day or two after their flu vaccine, but stressed that that is a good thing.
"[Symptoms mean] the body is mounting an immune response," Doctor Omar said. Adding, "In case you get infected with the virus, your symptoms will be much lesser than a person that contracted the flu without a vaccine."
Doctor Omar said that it is a good idea to make sure you are up to date with COVID vaccines to be better protected in both the fall and winter seasons.
And if you or people close to you get sick, Doctor Omar suggests wearing a mask and practicing good hygiene such as washing your hands.
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Following is a summary of current health news briefs.
Kenvue tempers annual profit view on soft demand for cold, flu medicines
Kenvue on Thursday warned that a longer summer season in the northern hemisphere would hurt sales of its cold and flu medicines this year as the Benadryl maker cut the higher end of its annual profit forecast range. Shares of the company were down 3% in premarket trading.
GSK's common respiratory virus vaccine shows potential in adults aged 50-59
GSK said its vaccine for respiratory syncytial virus (RSV) showed positive preliminary results in a late-stage trial to protect adults aged 50 to 59 from the disease that causes thousands of hospitalisations and deaths annually. The British drugmaker's shot, called Arexvy, met the primary goal in the Phase-III trial of eliciting an immune response in adults of the reported age group who are at an increased risk of catching the virus due to certain underlying medical conditions, the company said on Wednesday.
Bristol Myers says it needs another year to hit target for new drugs
Drugmaker Bristol Myers Squibb on Thursday pushed back by a year the time frame for its current new-product portfolio to hit $10 billion in sales as the ramp-up of new drugs including anemia treatment Reblozyl, psoriasis drug Sotyktu, and multiple sclerosis drug Zeposia takes longer than expected. Shares of the drugmaker fell more than 5% to $53.5 before the bell. They are down over 20% this year, while the S&P 500 index is up nearly 10%.
Labcorp beats quarterly profit estimates on strength in routine testing segment
Laboratory Corporation of America topped Wall Street expectations for quarterly adjusted profit on Thursday, as strength in its routine diagnostics business more than offset weak COVID test sales. U.S. lab testing companies including Labcorp rival Quest Diagnostics have seen a rebound in routine test volumes with people returning for regular health checkups that had been deferred during the pandemic.
Injected version of Eisai/Biogen Alzheimer's drug works as well as IV Leqembi
An injected version of Eisai and Biogen's Alzheimer's drug Leqembi works as well as the current intravenous version at removing toxic brain plaques, according to an analysis presented by Eisai on Wednesday. A weekly shot form of Leqembi, given as two consecutive injections, could simplify use of the groundbreaking Alzheimer's treatment, potentially allowing patients to receive the drug at home instead of traveling to an infusion center twice a month.
Pfizer, BioNtech say flu-COVID shot generates strong immune response in trial
Pfizer and German partner BioNTech said on Thursday that their vaccine to prevent flu and COVID-19 generated a strong immune response against strains of the viruses in an early- to mid-stage trial. The companies said they plan to start a late-stage trial in the coming months.
Merck quarterly profit tops expectations on COVID pill surprise
Merck & Co on Thursday reported higher-than-expected results in the third quarter on surprisingly strong demand for its COVID-19 treatment, primarily in Japan, and raised its annual sales forecast for the therapy. Sales of molnupiravir, the COVID-19 antiviral pill sold under brand name Lagevrio, jumped 47% to $640 million in the quarter, crushing Wall Street estimates of $120 million, according to LSEG data.
Medical equipment maker West Pharmaceutical raises 2023 profit forecast
Medical equipment maker West Pharmaceutical Services on Thursday raised its 2023 adjusted profit forecast for a third time, benefiting from a stronger dollar. The company, which makes products used to deliver and package injectable therapies, also beat third-quarter estimates for profit.
Boston Scientific raises profit forecast on strength in heart devices unit
Medical equipment maker Boston Scientific raised its annual profit forecast and beat estimates for third-quarter profit on Thursday as a post-pandemic rebound in elective surgeries boosts demand for its heart devices. A steady recovery in surgical procedures that were deferred during the pandemic, especially by older adults, as well as easing staffing shortages at hospitals have increased demand for medical devices.
US CDC recommends routine use of Bavarian Nordic mpox vaccine for adults at risk
Danish pharmaceutical company Bavarian Nordic said on Wednesday a U.S. Centers for Disease Control and Prevention panel has voted in favor of recommending the routine use of Jynneos vaccine for adults at risk of mpox. The CDC's Advisory Committee on Immunization Practices (ACIP) voted to recommend that individuals 18 years and older with certain risk factors should receive two doses of Jynneos.
(With inputs from agencies.)
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Hundreds of thousands of Albertans rolled up their sleeves in the first week of Albertas new immunization campaign.
According to data released Thursday, 312,072 doses of flu shots were administered in the week of Oct. 15, representing 7.8 per cent of all Albertans. Of all children aged six months to four years, 4.6 per cent got their flu shot.
And 215,224 doses of the XBB-targeting COVID-19 immunizations were put into arms of 5.2 per cent of Albertans.
The province made both shots widely available to the public on Oct. 16.
Initially, Alberta Health limited the number of doses pharmacies was able to order to 100 COVID-19 doses to ensure an equitable distribution across the province and to limit waste. The province raised that limit to 350 on Oct. 23.
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1:43 Edmonton pharmacies busy after first week of flu and COVID vaccines
Since the start of the respiratory virus season at the end of August, pharmacies have given out more than 90 per cent of COVID doses and more than 80 per cent of flu doses.
Calgary and Edmonton zones have seen the highest uptake in both types of immunization, with the South zone close behind.
In addition to preventing severe disease and death, scientists believe the new XBB-formulated COVID vaccine can better help prevent people from catching the airborne virus.
Aerosol scientists say properly-used high-quality masks like N95, KN95 or KF94 masks are highly effective at preventing infection.
0:25 Patients with severe mental illnesses more likely to die from COVID-19, new research shows
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In the week ending Oct. 21, 222 more Albertans were hospitalized for COVID and 11 were admitted to ICUs.
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All age ranges were represented in the new hospitalizations, and Albertans aged 40 and older were added to ICU.
The province added nine more COVID deaths that week, bringing the pandemic total to 5,956. One of those new deaths was of an Albertan in their 40s.
The positivity rate on PCR tests remained high at 17.8 per cent, the same as the previous week.
Influenza numbers also saw increases.
There were 57 more lab-confirmed cases, 14 more hospitalizations and two more ICU admissions.
2023 Global News, a division of Corus Entertainment Inc.
Popular on Variety
Devo was, and is, the ultimate future-proof band. When they first entered the public consciousness in the late 70s, Mark Mothersbaugh, Gerald Casale and company seemed impossibly ahead of their time in a primitive-futurist kind of way and they still do. Theres very little that you could consider dated about the 50 cuts on their new career retrospective, 50 Years of De-Evolution 1973-2023, since their worldview always kind of seemed to be trained on offering up dystopianism with a smile and a jacked-up synth-rock beat. De-evolution, for better or worse, is timeless, and so, apparently, are the men who introduced it to the world.
Beyond the just-released Rhino collection, the band is engaged in a round of touring that will take them up and down the west coast through the first three weeks of November, including a show at L.A.s YouTube Theatre on Nov. 16 and a festival date in Orange County two days later. (Scroll down for the full list of dates.)
They admit they may not be timeless in every regard. Mothersbaugh tells Variety how it felt being on tour in Europe recently: I really enjoyed doing the European shows. It reminded me enough of the old days that it was fun. And I mean, we dont look the same. But when I was a kid I loved to go see Hound Dog Taylor and different old blues players. And youd look at their album covers and then youd see them in person and youd go, Whoa, thats pretty hardcore. Like, Oh, wait a minute, that was 15 years ago or 20 years ago, when the album came out. And so now you see kids in the audience give you looks like that. Theyre looking and theyre going, Wait a minute, whats this? He didnt have that on the Freedom of Choice cover. And you just give him a scowl and scare him a little bit.
We spoke with Mothersbaugh and Casale separately for this story, conjoining some of their quotes in a Q&A that has been edited for length and clarity. Among the subjects, beyond the new compilation and touring, we also hit on their early days as young alien types in Akron, working with Brian Eno, some brief encounters with Joni Mitchell and Mick Jagger now, at last, the story can be told about why Keith Richards wanted to physically harm Mothersbaugh and whether planet earth is doomed.
The tour listings on Ticketmaster say Devo: The Farewell Tour Celebrating 50 Years. But the word is, youre not really saying farewell, right?
Mark Mothersbaugh: God, its so irritating that somebody in our camp let the promoter write farewell tour so he could sell a few extra tickets. Thats irritating to me, but I think we probably wont be the first band that has more than one farewell tour. We can have a Hello! tour next, I guess, next year. Well do the Welcome Back Tour or something.
Gerald Casale: That was a promoter-run idea. They werent listening to us. We said, Listen, this is the 50th anniversary of de-evolution. So were saying farewell to the first 50 years of de-evolution because theres going to be a lot more. Because youve got to agree that de-evolutions real and exponentially ramping up in front of all of our faces. And they just wanted to run with farewell for ticket sales. I think clearly if Devo was going to do a farewell tour, we wouldnt call it that. I would call it the Beginning Was the End tour, with a snake eating its tail with a Devo hat on. And I would reconnoiter the show and add more video interstitial elements and almost tell a historical narrative.
Mothersbaugh: Are you coming to the show?
Yes, absolutely.
Mothersbaugh: Well, then, if you come, I want you to also put it in your mind to stay healthy and I want you to come to 2073. I want you to come to our 100th anniversary show. We may not be there in flesh. We might be like those little robot things that deliver food around West Hollywood. But if we have all our sentient thoughts in that one unit, who knows? We might find out its even easier than being flesh and blood. We might like it better. But just keep it in mind that you want to be at the 2073 show.
I may have to send my avatar to that one, to watch your avatars.
Mothersbaugh: Well make sure you get your computer.
With the new collection, did you get very involved with that or just kind of sign off on Rhinos efforts?
Casale: Oh, we actually were working in close collaboration with the people at Rhino. They wanted that, and of course we wanted the same. So I feel really good about how it came out, and I think we curated it pretty well. And I like the package. You know, maybe 20 years ago, WEA out of Japan assembled a complete collection of every release we ever made on Warner as a collection of CDs with the original artwork and everything, just scaled down, in a box. It was really beautifully done and well thought out and kind of a novelty, and thats the only other thing Ive ever seen that was really quality. I felt like we needed this.
Mothersbaugh: I helped with graphics and that area, mostly. And also, there are a lot of recordings down in my basement here, right underneath where Im sitting [at his headquarters/studio on Sunset Blvd.). So I had a lot to do with collecting all that stuff, and then I let people that are more passionate about what songs to choose do that, because for me, my favorite Devo songs change every day. I have to go look at it again, because I dont have it in front of me. But I always like it when something Booji Boy sings is on (a project), so I hope theres a Booji Boy song on it.
Do you feel like its pretty obvious what people want in a collection like this? Or were there any sort of eras or songs where you were thinking, Okay, heres a chance to give this a little bit of an airing again, things that were not hits.
Casale: The answer is yes to all of that. With Devo, hits and misses are really an irrelevant misnomer kind of thing. Its either sounding more in the zeitgeist or way out, far out on the fringe. We like it all because we were an experimental collaborative group, and we werent cynically trying to write hits. So if we put something on a record, we liked it. And some of those things were esoteric tastes that a lot of people didnt like and other things connected with a larger group, so we span that whole gamut.
A bit earlier than this new set, you had a limited-edition collection that just focused on your earlier, pre-commercial years, Art Devo.
Mothersbaugh: Those actually required more digging around the basement than the Rhino release. I like both releases, because they do have a different tilt to each one, and we tried not to overlap, though Im sure theres a couple things that do. But that one is a lot of stuff that nobodys ever heard. Matter of fact, I hadnt even heard a lot of the stuff till we dug the tapes up and started transferring them to digital and cleaning them up. I like both of them. They have different mandates that complement each other.
Youve said that when you were coming up in Akron in the mid-70s, there were basically two clubs in the area you could play without getting physically attacked, or something like that. Fair to say you felt alienated from the culture of your contemporaries at the time?
Casale: I guess we were alienated, but we felt more like aliens. We werent alienated like, you know, existential punks or something. We felt like we were looking at a world that seemed like another planet. Itd be like if you were an alien in a spaceship with a monitor and you were just watching life on earth and commenting on it. Thats how removed we felt.
Its always fascinating to look back at musicians in the 70s, when we were coming out of the counterculture years, who were resisting that as well as the old culture that the counterculture was supposed to be rebelling against. Artists like yourselves who didnt have a lot of regard for maintaining traditions of any sort, musically or in your attitudes.
Casale: Yeah. I mean, we still were using 12-tone scale and mostly 2/4 and 4/4 beats although we got into 7/4 and 11/7 and a couple other wacko things. I just think that when any counterculture congeals into orthodoxy and becomes the thing that it railed against, thats when something pops out on the other end, like a carbuncle. And thats what started happening, these things that didnt fit the mold and certainly werent part of what was driving FM radio and stadium rock, You heard Kraftwerk, or you heard Giorgio Moroder, or garage-band stuff out of New York, like what Suicide was doing. Then came of course the Sex Pistols and the Clash, and it was just a revelation, at least for me. I saw the Damned in 1977 at CBGBs. I saw Patti Smith and saw Television and it was like, OK, somethings really happening, and were not isolated. Other people are out there thinking what we were thinking in Akron, but we didnt know that they were doing that and t hey didnt know about us.
But for a Patti Smith or Television, costuming is not going to be a big part of it. Did you feel like there were antecedents for some of the theatrical or really conceptual stuff?
Casale: Sure we did. In college, I studied art history extensively and had a great professor who showed us all the stuff Id never seen before during the Bauhaus era. Dadaists were actually doing performance art before there was a word for performance art. And they would put on these theatrical performances that were confrontational, and they would wear outrageous costumes, designed to piss off the audience, actually, or be clowny, or whatever. And of course, the immediate antecedents were the Beatles and the early 60s London scene and, frankly, American R&B people trying to look good in cool suits and flashy clothes that made them appealing. But we took it more from the Dadaists: OK, were meta. Were gonna wear these three industrial suits that are foolish-looking by many peoples standards, but well be able to rip them off because theyre disposable, and well be able to use it as a theatrical device live. It was really effective, and we were multimedia on purpose from the beginning, and making short films was part of the mantra. It was confrontational and we would get threatened, attacked, beer bottles thrown at us, you know, people jump on stage, rip the microphones out of our hand, push us around all of it happened. And of course that excited us. We thought, wow, if these people that were looking at hate us that much, lets keep doing it.
Because we were so isolated in these basements and garages, we honed our act. So we showed up on the scene fully formed, and people were stunned, either positive or negative. But I think thats what sold David Bowie, Brian Eno, Iggy Pop; they all got it. And we found ourselves in Germany with Connie Plank and Brian Eno and visits from David Bowie in these insane, intense, 12-14-hour days in a barn for three weeks in the winter.
Youve said Eno was great as a producer of your first album because he kind of let you do your thing. And then he added a lot of ideas that didnt really make it onto the finished mixes.
Casale: Yeah, it was funny because he had evolved. Not de-evolved he had moved on from that guy that we knew as playing atonal outrageous synth pieces over Roxy Music songs and with a feather boa and the hair. He became this Zen gentleman by the time we met him again, and he had moved on to the Music for Airports and his Oblique Strategies card set. I think what he was trying to do is take these brutalists from Akron that were thoroughly immersed in this industrial, aggressive, challenging sound, and he was trying to make it more beautiful. He was trying to install spirit and harmony into it. And of course we had lived with this stuff and wanted the world to hear the songs the way we heard them. He was getting frustrated; if hed play this beautiful line over the top of one of our songs, or a beautiful harmony, then slowly during the mixing session, Mark and I would be pulling the faders down. But he was fun to be with, because he was such a smart guy so thoughtful and articulate.
And somehow you became more palatable to the wider rock culture despite yourselves although there were deliberate shifts in sound.
Mothersbaugh: For Art Devo, I pulled out a lot of the stuff out of the pre-Warner Bros. days, back when Bob and Jim and Jerry and me were the band, because that to me was kind of Devo at our most high-art position. After that, we decided that it was going to require a subversion for us to enter the market. We thought people were just going to love us for what we were, and they didnt. So we thought, OK, plan B: Were going to sneak vitamins and minerals into their food without them knowing it. Were going to use Madison Avenue techniques. And we started making our things more succinct, more easy to understand, and it worked.
We always thought, Wait a minute. This should be bigger. How come nobodys paying attention to what were doing? But we knew it wasnt going to be easy. I remember a time when Joni Mitchell, who had the same manager as us, and I bumped into each other in the hallway at the managers office. And she goes, Are you Mark Mothersbaugh from Devo? I go, yeah. She goes, Hey, Im going to be in this movie. And Im carrying a ghetto blaster on my shoulder, and I want a song to play on the ghetto blaster. And Im thinking I want it to be that song on your new album, Swelling Itching Brain. Do you mind if I use that? I go, No, that sounds great! Why do you want that song? She goes, Because its the most irritating, obnoxious song Ive ever heard in my whole life. And I go, Please use it.
So Joni Mitchell has somehow deliberately listened to music she considers obnoxious and abrasive. What was the result of that?
Mothersbaugh: Well, I dont know what the part was. I dont even know what the movie was. It just made me laugh that thats what she had to say to me.
How did some of the other established rock giants relate to you?
Mothersbaugh: I remember back in like 81, the Rolling Stones were recording at the Power Station the same time Devo was. This old guy who looked like a grandpa came upstairs in a big knit wool sweater and he goes, Hey, would one of you guys play synthesizer on my record? And I look at him and Im like, Thats Charlie Watts. I went downstairs and he and Mick Jagger and Bob Clearmountain were sitting in this room and they had this song called Worried About My Baby or something. [Editors note: likely Worried About You.] It wasnt a bad song; it wasnt their best song. They said they wanted to put a synth on it, and to me, that seemed impossible first off, because I listened to the song and I was like, That aesthetic, a synth is gonna trash it; thats not gonna make it better. That was because I thought of synths as something aggressive and in-your-face They got really stoned, and we started playing around, and I brought out a vocoder that Bob Moog had loaned us the same one Wendy Carlos used for Clockwork Orange. It had a great sound and we used it for a couple songs on our record. I plugged a headphone into the mic input, and I had a synth sitting on their piano, and I ran the synth into one side of it, and then I had Mick Jagger take the headphone Ive never told anybody this, because for a while I was really embarrassed that I ever did it.
I got Mick Jagger to put a pair of headphones on sideways. He had this rhythm he wanted to move up. I said, well, how do you want the synth to sound? And hes going boom, bop, bop, doo, bop, doo, bop. And so I put a sound into the Prophet synthesizer and he was doing that into a vocoder. You would have had to have done the kind of synthesizer sounds that I hated to put a synth on that song something tasteful and small, in the back of this kind of romantic, soft, lazy song. On one hand, I was totally freaked out that I was in the same room with those guys. And on the other hand, I was totally freaked out because I thought, This song, the last thing it needs is a synthesizer. And so I put this thing on his face and we put this part out on their song, and I think you can hear a tiny bit of it in the song at the end of the album when it came out. But um, why am I telling you that story?
Keith Richards was friends with my brother, Bob. He later told Bob, What guy in your band put that part on my song? I want to stab him in the heart with a knife.
Certainly Devo entered the culture even in subliminal ways. The words devolve and de-evolution werent really a concept before you guys were around, and now you hear those words all the time. Like, every time there is a political debate.
Casale: Yeah, it quit being a polarizing term. It quit being something that pissed people off. Now its just like oh, yeah, de-evolution, right you know, its real. As a matter of fact, last year the Websters Dictionary, they pick words of the year. Last year it was Devolve. They showed hundreds and hundreds of references. mostly political articles, some social science articles and behavioral articles about sociobiology, but its everywhere. And youre correct when now you watch the news and it all seems like an episode of Black Mirror. I mean, you dont need the Onion anymore because its all the Onion, right? Its that devolved.
Mothersbaugh: I have to say, the word de-evolution first became a word in our vernacular in the 30s. It was Christians having a response to Darwinism, and they made jokes and ridiculed evolution. Not long after Jerry found the book In the Beginning Was the End: How Man Came into Being Through Cannibalism, in which they talk about de-evolution, I found a pamphlet later on from the 30s by a reverend from Ohio, called Jocko Homo: Heaven Bound King of the Apes. And you open it up and theres a picture of a staircase on the way to heaven, and every stair says like, World War I, World War II, murder, insanity, drug use and theres an ape sitting there chewing on a leg bone, knelt down in front of the staircase, and then standing up behind him, smiling, theres a devil holding a pitchfork, and across his chest it says, De-evolution. I think thats maybe the oldest use of that term, and so it did exist back in the 30s.
Casale: Things have been borne out a little bit, unfortunately, beyond my worst fears. Beyond my most dystopian nightmare. You can go back to Obama. The blowback on poor Obama and his years that happened is just phenomenal. Its like H-bomb time. Trump and his cohorts and the people in the House, these guys are serious. They are authoritarians, and they do not believe in democracy, and theyre willing to bring it down.
There is the saying about the arc of the universe bending toward justice, and right now, de-evolution seems more like it.
Casale: Its more like what George Orwell said about history is the boot coming down in the face of humanity over and over again.
And, yet, with Devo, that can sound a little fun while that medicines going down.
Casale: Thats it. We threw in a spoonful of sugar.
Mothersbaugh: We were hoping that people were going to avert the kind of stuff thats facing us right now, and they could have, but greed and stupidity allowed us to keep pushing it further and further to the brink, and now were going to see if we can back it up or not. And we may not. Maybe humans have destroyed the planet for all nature. Hopefully we havent. I think before I met Gerry. I read this book called Population Bomb, by a sociologist in the U.S., and everybody hated him and wrote hate letters to him for this book. But he said: Do the math. Humans have consistently doubled, tripled, quadrupled to the point where we will have depleted the oceans and have eaten everything that you can eat on this planet. And the only hope for planet earth is that the planet will retaliate against humans and kill us off with a virus and save Planet Earth. He said, the other possibility is nuclear war, and then thats bad for all of nature. And so, at 19, I pledged I would never have kids because of that. I said, Im not bringing more humans onto the planet. Thats the one thing I could do. Im not famous. Im not rich. Nobody cares about what I think, but I could be one of the people to volunteer not to bring another human on the planet.
Did that decision continue to feel good over time?
I stayed with that, until 20 years ago when I got married, and my wife goes, OK, I know you said youre not going to bring more humans onto the planet, but what if we adopted somebody that was already here? That wouldnt go against your tenets, would it? And I was like, Oh, you got me on that one. And so we ended up adopting, and I remember up until the very moment that we picked up our daughter in China, the closer we got to it, I thought, My wife is insane. Why in the hell are we doing this? Im an egotistical, self-centered artist. Hows that gonna be? Thats just gonna get in the way, and Im too old for kids. And then I saw the baby that Id seen pictures of for the last three months because shed been abandoned, and I remember looking and I said, Thats Margaret. Thats my baby. Im a dad. And it was the heaviest thing that ever happened to me in my whole life. This door opened and it was like I felt this primordial urge to be a father. And I just remember: I both thought my wife was the smartest human Id ever met in my whole life at that moment, and I also thought: Theres no hope for humans. Its going to take the virus killing us off to save planet Earth. Well never be able to do it ourselves. Because it was so intense, the feeling of being a dad. I totally got it. And I got two kids and thats the best thing that ever happened to me in my life.
So do you try not to be too pessimistic about the world, just for their benefit?
Mothersbaugh: Oh, you know what? Honestly, Im still not that pessimistic. Ive got a feeling that the people that are in control of governments around the world are insane, and that the people that want to be the president of this country, theyre the crazies, and its like, I could imagine that guy holding the steering wheel and jamming on the gas going, Hey, Im 85. I dont care and then going over the edge and taking everybody with him.
But I also imagine that theres enough people in this world that have kids and thatll help if you have kids, and have a connection to the future that are going to say, Were not going to let this guy do that. Were not going to let some oligarch somewhere, whatever country that oligarch is in, destroy everything for everybody. So Im still voting for that side of the card.
Moving back from the fate of humanity to this tour Mark, youve said that youre comfortable playing the classic material. And youve said that if you go see a band of a certain age, you dont necessarily want to hear fresh stuff. Is that how you feel, being out there and doing shows this year?
Mothersbaugh: Yeah, honestly, I dont want to hear OK, pick somebody. Name a band, so I dont have to pick a bands name.
Like, the Rolling Stones?
Mothersbaugh: [not hearing] Who?
The Stones?
Mothersbaugh: Oh, OK, I thought you said something else. You know, I thought I was invincible back in the 70s [with hearing issues], and I never used in-ear monitors or anything. And playing with orchestras is deceptively loud, I gotta tell ya. If youre sitting in Abbey Road and youve got a hundred-piece orchestra in the next room crashing away on Thor: Ragnarok or Lego or Cocaine Bear, even, theyre pretty goddamn loud! I thought I was invincible, but I wasnt.
But yeah, the Rolling Stones oh, God, I want to hear the old stuff. I want to hear the stuff that was on The TAMI Show and their very best stuff. I want to hear Last Time and Get Off My Cloud and definitely Satisfaction. Street Fighting Man and anything earlier than that is great as far as Im concerned, and then the other stuff You know, sometimes you just keep doing it anyhow, and I guess that stuff means something to somebody. And it might be that somebody that was 12 years old when they first heard Wild Horses, and they love it. But, to me, Wild Horses, thats when I said, Uh-oh, its over for them. Thats how I felt when I heard it. I thought, Yeah, I dont need to hear another new Rolling Stones song.
I remember you saying in the past, Gerry, that as some of the records got pretty synthesized at some point, maybe the fact that Devo rocked sometimes got undervalued. So when you do shows now, do the shows rock? Is that safe to say?
Casale: Yes, they do. People cant believe it, and thats what they love. They cant believe that these septuagenarians are actually playing and rocking out. We always did, but it got bypassed. But now its featured and people talk about it.
You guys tour fairly rarely. What does it take for you to get back in kind of a touring mindset and play those songs?
Mothersbaugh: I got out of touring just because, every night I was on stage, I used to throw myself around, and I would make enough noise that, by the end of the show I remember being 26 or 27 and going, This is really hard. I dont know if I can do this when Im 30. And now Im 73, and you know, Gerrys even older than me. But he was jumping around on stage on these shows and he looked great. Bob Mothersbaugh plays better than he ever did. We have a guy, Jeff Friedl, playing drums now. Hes excellent. And Josh (Hager) on guitar and keyboard, replacing Bob Casale, is really good. And Im hanging in there. You know, I had to modify some stuff Im not cannonballing into the audience anymore. But based on the reaction from the audiences, I think people like it and think it sounds pretty good. So Im enjoying that.
Its kind of fun to get out of this room you see behind me. I sit here every day for the last 30 years, writing music for like 150 different films and television series and video games. You know, my ass got too wide because of that.
Devo tour dates:
Nov. 2 Santa Cruz, CA
Nov. 3 Paso Robles, CA
Nov. 5 San Francisco
Nov. 7 Seattle, WA
Nov. 8-9 Portland, OR
Nov. 11-12 Del Mar, CA
Nov. 14 San Francisco, CA
Nov. 16 Inglewood, CA
Nov. 18 Huntington Beach, CA (Darker Waves festival)
The yeast Candida albicans can play a part in regulating the immune system.Credit: Eye Of Science/SPL
An imbalance of fungi in the gut could contribute to excessive inflammation in people with severe COVID-19 or long COVID. A study found that individuals with severe disease had elevated levels of a fungus that can activate the immune system and induce long-lasting changes.
The work, published on 23 October in Nature Immunology1, raises the possibility that antifungal treatment could provide some relief to people who are critically ill with COVID-19.
We know inflammation is driving severe disease, says Martin Hnigl, a clinical mycology researcher at the Medical University of Graz in Austria, who was not involved in the study. This work, he says, provides a potential mechanism of disease-causing inflammation that might have been overlooked.
Trillions of microorganisms live in and on our bodies, helping us to digest food, protecting us from harmful pathogens and more. Although much of the microbiome consists of bacteria, past research has shown that the fungal portion the mycobiota interacts with the immune system, too2.
Previous studies have shown that many people with COVID-19 have guts with altered microbial make-ups and disrupted protective barriers, which could allow pathogens to enter the blood3,4. And some individuals critically ill with COVID-19 have contracted dangerous fungal infections in their lungs5.
What triggers severe COVID? Infected immune cells hold clues
Immunologist Iliyan Iliev at Weill Cornell Medicine in New York City and his colleagues wanted to further investigate the link between the mycobiota and COVID-19. The researchers examined blood from 91 people hospitalized with the disease in 2020. Almost three-quarters of these people had severe COVID-19, who received more than six litres of supplementary oxygen a minute or invasive mechanical ventilation, whereas the rest had moderate or mild disease.
Compared with 36 individuals who had never tested positive for SARS-CoV-2, people with severe COVID-19 produced about four times as many antibodies against three fungal species commonly found in the gut, including the yeast Candida albicans. A high prevalence of antibodies suggests that these people had elevated amounts of those fungi. Faecal samples collected in early 2021 from 10 people with COVID-19 also showed that they had higher overall levels of gut fungi, especially of Candida species, relative to 10 healthy individuals. For these people, the abundance of Candida was positively correlated with disease severity. The presence of some fungal species, C. albicans in particular, has been shown to activate the immune system6.
In a subset of people with severe COVID-19, the number of antibodies against C. albicans in their blood was linked to the number of immune cells called neutrophils, which can trigger inflammation.
When the researchers infected mice with C. albicans extracted from people with severe COVID-19, and then infected them with SARS-CoV-2, they observed that more neutrophils invaded the animals lungs and activated an inflammatory response than in mice with SARS-CoV-2 alone. If they gave these mice an antifungal drug, it lowered the number and activity of neutrophils.
The study also found that people with severe COVID-19 continued to have raised levels of antibodies against C. albicans and neutrophil precursors primed to counter fungi long after they had recovered from the disease up to one year later in some people. These factors hint that mycobiota changes during a SARS-CoV-2 infection could contribute to inflammation associated with long COVID.
COVID lockdowns altered babies microbiomes
Theres a number of theories of what might trigger persistent symptoms after COVID, says Aran Singanayagam, a respiratory immunologist at Imperial College London. Microbial dysbiosis, either of the gut or the lungs, is one major theory that people are proposing, so I think this adds weight to that theory.
Researchers agree that more work is needed to probe the link between gut fungi and COVID-19. It remains unclear whether the observed changes to the mycobiota in people with COVID-19 resulted from the disease or preceded it and made people more susceptible, says Singanayagam.
If future studies reveal more about the mechanisms involved, existing antifungal treatments could be repurposed to help people with COVID-19. Iliev hopes that this work will make people start thinking about those common types of biology that we see in very different diseases and how we can leverage that.
We want to be done with Covid. But the virus isnt done with us.
While cases are not as high as they were at the end of this summer, newer variants are spreading, and experts predict that the patterns often seen over the last three years of the pandemic the temperature drops, people cluster indoors, cases rise will play out again this fall. That means it might be time to take stock (yes, again) of how you can minimize your risk.
It continues to be a moving target, and I think that continues to be hard for people, said Dr. Peter Chin-Hong, an infectious disease expert at the University of California, San Francisco.
As the holiday season approaches, here is a quick refresher on how to navigate the pandemic.
Youve heard it before, youll hear it again: Masks can help you protect yourself and others from becoming sick. So can washing your hands thoroughly and not touching your face with unwashed hands, said Dr. Joseph Khabbaza, a pulmonary and critical care doctor at Cleveland Clinic.
The updated Covid vaccines can also reduce your chances of being infected, and especially cut down on your risk of serious illness, said Dr. Ziyad Al-Aly, the chief of research and development at the V.A. St. Louis Healthcare System.
Rapid tests are also a vital tool. (You can order four free tests per household from the federal government.) Testing when you have symptoms, or after a confirmed exposure, can help determine if you have the virus. Keep in mind that you should take two tests, 48 hours apart, for a more complete picture. If you do have Covid, you may qualify for Paxlovid, which significantly reduces the risk of severe disease and death but you need to take the medication within five days of symptoms starting.
Risk largely boils down to how crowded a place is and how long you spend there. If youre popping into a convenience store, for example, your risk is probably minimal; if youre lingering unmasked for hours in a full concert hall, its higher.
Any time youre indoors with a lot of people, the risk is still there, said Dr. Marc Sala, co-director of the Northwestern Medicine Comprehensive Covid-19 Center in Chicago. Its a good idea to wear a mask on the subway or bus. Planes are likely less risky because of their ventilation, but you still may want to mask, especially when boarding and deplaning.
For any indoor activity, like going to a bar, there are degrees of risk, said Dr. Chin-Hong. How busy is the place? Can you sit by an open window? Newer buildings tend to have better ventilation, and the bigger a place, the more spaced out you can be from other people, which lowers your chance of infection. And anything becomes riskier when cases are rising. Its tricky to find clear data on Covid-19 cases, but you can check local hospitalization rates and wastewater data to get a better sense of your risk.
As the coronavirus has evolved, the amount of time between being exposed and developing symptoms has shortened, Dr. Chin-Hong said. Most people now tend to test positive three days after they have been exposed to the virus, he said. But for many people, it takes a full week to test positive on a rapid test. (Molecular tests are more sensitive but harder to find outside of a doctors office.) Once youre past the one-week mark, though, youre likely in the clear.
It depends on how risk-averse you and the people around you are. It also depends on who you are spending time with if youre visiting an older relative, for example, you may want to reschedule.
And you may want to tell those youre spending time with that you are not feeling well.
Just like you inform people when youre coming late, you inform them with the symptoms you have, and you negotiate with them, Dr. Chin-Hong said. You might move a dinner party outside, for example, or shift plans to another night. Testing is often the only way to determine whether sniffles are due to a cold, the flu or Covid.
If you have a fever, stay home, Dr. Chin-Hong said. Thats a sign youre likely infectious.
If you caught the coronavirus in the past three months, youre fairly well protected against it. You can still become reinfected within that window, but its far less likely, because the variants circulating are similar.
Consider taking extra precautions, like limiting the time you spend around others unmasked in the five days before a big gathering. Be vigilant about your symptoms, Dr. Khabbaza said. You may also want to test beforehand.
Its hard to eliminate risk completely, Dr. Al-Aly said. But you can reduce ones risk.
Oklahoma Governor, Kevin Stitt has decided to allocate the remainder of the 'GREER II' funds to education purposes.
Monday, October 23rd 2023, 7:28 pm
Governor Kevin Stitt has allocated the remaining GEER II funds, or COVID-19 relief funds to be spent on education purposes. Stitt has allocated almost $18 million to be spent on six different projects, helping students recover from the pandemic.
The GEER funds were allocated to governors across the nation, to spend on education proposals of their choosing.
After hundreds of thousands of GEER funds were flagged in a federal audit, the Oklahoma Office of Management and Enterprise Services has been tasked with overseeing the allocation of these most recent funds. They have also hired an outside contractor for the oversight and administration of the funds.The recipients have until January 31 to spend the allocated funds.
Here is the full breakdown of costs and projects provided by OMES:
1:eDynamic / Learning Blade: $400,000.00 This project will help develop Oklahoma students academic skills while improving their interest in high-demand jobs by increasing their awareness of careers. These systems are proven to increase student awareness and interest in STEM, computer science, and CTE pathways while also addressing learning loss. The Learning Blade resource prioritizes students who have been disproportionately impacted by COVID-19 by providing easy access to STEM, CS, and CTE resources that can be used in school, blended or at home
2: DonorsChoose: $11,610,000.00 This project will allow preK-12 Oklahoma public school teachers to request classroom resources to support their students' in-person learning recovery from the pandemic.
3: Special Care: $600,000.00 This project is focused on supporting teachers and support staff who served a greatly underserved Oklahoma population during the pandemic children with special needs and their families. Through this program, Special Care will receive funding for salaries of new positions and retention bonuses for eligible teachers and support staff that are working to support special needs children
4: Boys & Girls Clubs of Oklahoma County $1,880,000.00 This project for the Boys and Girls Clubs of Oklahoma County is focused on helping students around the Capitol Hill/south OKC location who were negatively impacted by the effects of COVID-19. This program will support them through physical building enhancements to host engaging programs, such as academic enrichment/tutoring, STEM activities, recreational and competitive sports, programs in the arts (dance, visual arts, music, and drama), life skill development, special interest clubs (i.e. photography, chess, creative writing, etc.), workforce development and more
5: Boys & Girls Clubs of Oklahoma County $200,000.00 This "Club-on-the-Go" Mobile Clubhouses project with the Boys and Girls Club of OK County is focused on supporting students who have been disproportionately impacted by the pandemic and will bring the Boys and Girls Club student development efforts to kids beyond BGC physical locations and meet kids where they are.
6: Healthy Schools Oklahoma $2,500,000.00 This project is focused on providing health and wellness resources to elementary schools across the State of Oklahoma. This project will help address educational gaps created by the COVID-19 pandemic by including evidence-based learning and wellness strategies for schools.
7: Guidehouse $250,000.00Assisting in oversight and administration of GEER II
8. $272,950 for other administrative costs.
In this Norwegian nationwide registry-based study of primary care patients we found that the risk of fatigue or shortness of breath were more than doubled 3 to 12 months after COVID-19 compared to a control group of unexposed persons. The likelihood for memory disturbance, other respiratory symptoms, pain in abdomen, chest and musculoskeletal system and headache were also significantly higher in the COVID-19 group.
The risk of fatigue, memory disturbance and shortness of breath varied with sex, age, education and country of origin among patients after COVID-19. These risk factors generally acted in the same way in the unexposed control group, but pre-pandemic registration of comorbidities was less associated with shortness of breath after COVID-19 compared to unexposed. Having had the same symptom before the pandemic increased the risk for fatigue, memory disturbance and shortness of breath after COVID-19, but the associations were weaker in the exposed than in the unexposed group. Yet, a higher prevalence of outcome symptoms among the exposed support the hypothesis that such symptoms may be attributed to COVID-19, also in a low-risk primary care population. Post-COVID-19 symptoms were more frequent among those who were hospitalised during the acute infection compared to COVID-19 patients who were not hospitalised.
This is a nationwide registry-based study including all persons with a positive PCR test for SARS-CoV-2 and all contacts in a GP list patient system for the whole population, ruling out potential bias from selection or loss to follow up. The diagnoses were recorded by GPs in a business as usual situation, which strengthens the generalizability of the findings.
Another strength was the comprehensive data of the chosen outcome symptoms, comorbidities, and GP utilisation before the pandemic.
Most of the included COVID-19 patients in this study were unvaccinated since vaccination started in Norway at the turn of the year 2020/2021. At the end of our inclusion period (20 February 2021), only 7.5% of the Norwegian population had had a first dose and 3.7% of the population had two doses vaccinated [21] of whom many were nursing homes residents not included in our study population, 85 years of age or older, or health care workers. Consequently, the present study can be seen as a baseline study regarding post-COVID-19 symptoms in a predominantly unvaccinated population.
A limitation of our study is that for GPs, it is common to register only one or two ICPC-2 diagnosis codes, while patients may have presented several problems in one consultation. This is likely to limit the number of symptoms that we identified from registered codes, resulting in underestimation of the symptom burden. Since the data are from GP consultations which do not capture all symptoms in the population, the present study cannot be interpreted as prevalence study of post-COVID-19 symptoms in the general population.
Also, under-registration of COVID-19 is likely, as not all infected persons were tested. This was particular the case in the first 23 months of the pandemic due to a shortage of test kits. However, during the first phase in 2020 the incidence of COVID-19 in Norway was low due to lockdowns. This is supported by a study among 27 700 randomly selected persons at the end of 2020 detecting antibodies against SARS-CoV-2 only among 0.9% of the sample, which is close to the prevalence in the population with a positive PCR test at that time at 0.8% [22]. Therefore, in the whole population without positive PCR test the undiagnosed cases represent a very low share and should have neglectable effect on the results in the current study.
Having had COVID-19 may alter the utilisation of healthcare, but according to a Norwegian study the increased use of GP services related to COVID-19 gradually decreased to a normal level during the first three months after COVID-19 [23].
The lack of a specific diagnostic code for post-COVID-19 makes it difficult to assess the epidemiology of post-COVID-19 health issues. Walker et al. [24] found little use of codes for post-COVID-19 introduced for British GPs and recommended more awareness on coding of post-COVID-19 symptoms to increase possibilities for research and care planning. The current study is based on diagnoses irrespectively of the GPs interpretation of a possible connection to the prior COVID-19.
Still, those who have undergone COVID-19 may be more alert to symptoms reported as post-COVID-19 and present them to their GP. GPs may also have altered their coding practice, being more attentive to and record symptoms that could be related to prior COVID-19. This could result in confirmation and detection bias in our study. If so, the differences between exposed and unexposed may be overestimated in the current study. However, this is a challenge in all studies on registered symptoms that may be related to a certain disease.
The number of individuals with positive PCR test for SARS-CoV-2 was not very high during the exposure period used in this study. This leads to a small number of individuals in some of the risk factor strata within the COVID-19 group, and this is also reflected in the wide confidence intervals for some RRs in Fig.3. The findings regarding these risk factors should be interpreted cautiously.
Determining the prevalence of post-COVID-19 symptoms in the population is methodologically challenging, including confirmation of infection (self-report, health care reports or registries) and approaches to define post-COVID-19.
The prevalence of symptoms reported in meta-analyses published early during the pandemic were generally much higher than our findings [12, 18, 19]. Not all patients seek a GP for symptoms and the GP reported diagnoses do not reflect all symptoms experienced by the patients. When an early meta-analysis reports a prevalence of fatigue of 23 to 60%, compared to 6% in the present study, this may reflect different patient populations. A strength of our study is that it is based in primary care and therefore closer to true population rates than hospital-based studies. A later study has indicated lower prevalence, with 6% reporting post-COVID-19 symptoms after three months and about 1% after 12 months, which is more line with our data [6]. Further, a Norwegian cohort study among young adults found no association between serological signs of COVID-19 and symptoms 6 months later [25], using the broad WHO definition for post-COVID [8]. However, they showed a trend for increased prevalence of postinfectious fatigue, in line with our findings of a highest frequency and HR for this outcome symptom.
Unlike previous studies, particularly those relying on self-reported symptoms [18, 19], we found a lower likelihood for psychological symptoms in the post-COVID-19 period. This could indicate that these symptoms were frequently mild and not perceived as a reason to consult a GP, or it is possible that GPs chose to code other symptoms during the visit. On the other hand, as shown by others, we found an increase in prevalence of anxiety and depression also unexposed, possibly related to a more general effect of the pandemic [26]. It is worth noting that registry-based studies tend to report a lower prevalence of mild mental health problems compared to self-reported surveys [27].
A Dutch study, using data from a large population-based cohort study initiated before the pandemic, was able to establish a control group like we did [28]. The diagnostic categories are not quite comparable to the GP diagnostic codes used in our study, but the findings are similar to ours. Also, a study on non-hospitalised patients from UK showed hazard ratio for fatigue, shortness of breath and chest pain in the post-COVID-19 period in line with our findings [4]. In a recent study from Norway based on SARS-CoV-2 positive cases at the turn of year 2021/2022 there was marked lower HR for most symptoms [3], with HR for fatigue of 1.24 and 1.29 for Delta and Omicron respectively compared to the HR of 2.1 in our study. That study reported HRs of 1.29 (Delta) and 1.69 (Omicron) for shortness of breath compared to 2.8 in our study. These differences can be explained by a shorter observation period, maximum 4 months as compared to 12, and different covariates, as we included pre-pandemic health problems. However, this may also indicate a decrease in risk for post-COVID-19 symptom later in the pandemic, and an effect of vaccination of most of the population at that stage.
Recently, based on 9764 tested persons in the US, an attempt was made to develop a definition on post-acute sequelae of SARS-CoV-2 infection (PASC) [29]. However, only around 1300 were unexposed and symptoms were self-reported. It was acknowledged that developing a better definition would require analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals. Our study may add knowledge to this field using a large sample of both exposed and unexposed.
In general, after various infections a minority of patients experience long term post-acute health problems [10]. Such symptoms are common across different infectious diseases, suggesting some common underlying mechanisms that, however, are poorly understood. In light of this knowledge, a post-acute syndrome following COVID-19 is not surprising nor exceptional.
Female sex, higher age, belonging to an ethnic minority group and a high disease burden prior to infection are documented risk factors for post-COVID syndrome [4, 5, 13, 30]. We found that the risk factors for fatigue, memory disturbance and shortness of breath were rather similar in exposed and unexposed. However, some minor divergences were found, as belonging to the age group 25 to 60 years was a stronger risk factor for fatigue in the exposed compared to the unexposed group.
In the literature, comorbid conditions are found to increase the risk for post-COVID-19 symptoms [4, 5]. However, using a score for comorbidities, we found no increase in relative risk for fatigue or shortness of breath with increasing number of comorbid conditions among exposed and a slight increase in risk for memory disturbance with three or more comorbidities. For shortness of breath, we found a lower relative risk with increasing numbers of comorbidities after COVID-19 compared to unexposed. This could indicate shortness of breath to be part of post-COVID-19 syndrome unrelated to previous diseases since the infection affects the respiratory system, whereas among the unexposed the risk increased with increasing comorbidity score. On the other hand, in our study the diagnosis shortness of breath might not have been registered if other diagnosed conditions were considered to explain the symptom by the GP, and this may more often be the case with lung symptom compared to fatigue and memory disturbance.
Outcome symptoms such as fatigue, memory disturbance and shortness of breath are common in the general population, and having had the same symptom before the pandemic markedly increased the risk for having an outcome symptom in the observation period. In clinical practice it is difficult or impossible to determine in each case whether a symptom actually was present prior to the infection, whether it is caused or aggravated by the infection or whether it appears by chance. This underlines the challenge using post-COVID-19 as diagnosis in primary care, as shown by low-frequent use of such a code when introduced in the UK [24] and also indicate that a composite explanatory model is necessary to understand the mechanisms underlying post-COVID-19 symptoms [10, 25].
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