Category: Corona Virus

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Expert shares advice for parents navigating pediatric influenza, COVID-19, and RSV this winter – Newswise

January 22, 2024

Newswise Coping with the challenges of parenting can be particularly stressful for those concerned about the flu, COVID-19, or RSV. With an increase in cases this season, parents are seeking effective preventive measures and safety guidelines for their kids. Dr. Christopher Pierce, the interim chair of pediatrics at the Virginia Tech Carilion School of Medicine, offers insights on managing these three illnesses.

This year, doctors are currently seeing high numbers of flu and this started a bit earlier than historically, says Dr. Pierce. Yearly flu vaccines are needed to give our immune systems a "reminder" of how to fight the flu, there is some added immunity that repeat exposure plays as well.

The prevalence of influenza among children has decreased early pandemic but increased over the past two years, which Dr. Pierce attributes to the heightened exposure to COVID-19 during that period. There was minimal influenza activity from spring 2020 through early summer 2022, which was a direct result of masking and social distancing.

He also says RSV is still prominent, but has begun a decline. RSV is more difficult to track as it is not reportable as are Flu and COVID, which means there is not a good way to keep track of these numbers.

Dr. Pierce says it is important to look for key indicators to assess the severity of your childs illness. Parents should look for rapid breathing, using accessory muscles such as "tummy breathing or "head bobbing, and if older children are complaining of not breathing well, would warrant an emergent evaluation. He says to also watch their level of alertness and fluid intake. Nonetheless, he stresses that reaching out to the primary care provider is the safest way to evaluate a childs level of illness and get the best care.

To differentiate between the three, Dr. Pierce recommends getting tested. Influenza, COVID-19, and RSV can mimic one another, so knowing which symptoms align with which illness can help parents. Overall, COVID-19 symptoms tend to be milder in children and the flu is more of the fever/aches/malaise. RSV is different for premature and younger infants as it can trigger lower respiratory symptoms known as bronchiolitis (not bronchitis) which can lead to respiratory distress which requires hospitalization to manage.

His biggest piece of advice - get the flu vaccine. It is the safest and most effective way to prevent the risk of hospitalization and death from influenza.

- Written by Sarah Hern

Dr. Christopher Pierce is the interim chair of pediatrics with the Virginia Tech Carilion School of Medicine (VTCSOM) and an associate professor of pediatrics. He is also the Chief of General Pediatrics at Carilion Childrens. His leadership has been instrumental in establishing Carilion Childrens Tanglewood Center, which opened in 2021, as the anchor for pediatric care for the region. Dr. Pierce joined Carilion in 2001 as a general pediatrician.

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Expert shares advice for parents navigating pediatric influenza, COVID-19, and RSV this winter - Newswise

Evaluation of psychological distress, burnout and structural empowerment status of healthcare workers during the … – BMC Psychiatry

January 22, 2024

Responses rate

An online survey was sent via email to healthcare workers (HCWs) from 48 different countries. Out of the 1030 participants, all completed the sociodemographic section, resulting in a response rate of 100%. A total of 730 participants completed the DASS-21 questionnaire (70.9%), 851 completed the MBI questionnaire (82.6%), and 712 completed the CWEQ-II questionnaire (69.1%).

The meanSD age of all responders (n=1030) was 38.889.63years (range: 2174years) and 54.4% (n=560) of them were male. The majority of participants were physicians (n=562, 54.6%), followed by nurses (n=279, 27.1%). Out of 1030 responders, 332 (32.2%) HCWs worked in ICU, 185 (18%) were from internal medicine, 118 (11.5%) werefrom emergency departments, and 109 (10.6%) werefrom anesthesiology. The majority of participants were working in Qatar (n=400, 38.8%) and India (n=161, 15.6%). The frequency of participants by other countries are available at Supplementary File 2 in Figure S1 and S2.

Among all responders (n=1030), 763 (74.1%) of HCWs had been working in areas designated for COVID-19 patients. Out of the 763 HCWs, 692 (90.7%) had been directly involved in the care or management of COVID-19 patients for9months (n=403/763, 52.8%) and for>9months (n=360/763, 47.2%). During the survey period, 435 (42.2%) of HCWs received specific training for COVID-19, while 595 (57.85) did not. The sociodemographic characteristics of participants according to working in the COVID-19 area are presented in Table 1. The main significant differences between HCWs who worked in the COVID-19 area and those who did not were observed in terms of age (P<0.001), specialty (P<0.001), level of education (P=0.008), working hours per week (P=0.047), working hours per week during the COVID-19 pandemic (P<0.001) and receipt of specific training (P=0.034).

Total and subscale scores of the DASS-21, MBI and CWEQ-II scales in all participants, as well as in HCWs who worked in the COVID-19 area or not, are presented in Table 2. Among all responders (n=730), the median (IQR) scores of stress, anxiety and depression were 12 (618), 6 (212), and 6 (214), respectively. The results of subscale scores based on categories groups showed that the majority of HCWs had normal level of stress (n=364, 49.9%), anxiety (n=391, 53.6%) and depression (n=433, 59.3%). The median (IQR) scores of emotional exhaustion, depersonalization and personal accomplishment in all responders (n=852) were 22 (1132), 6 (311) and 37 (3142), respectively. The results of categorized subscales indicated that the HCWs experienced high emotional exhaustion, while low depersonalization and personal accomplishment according to MBI scale. Furthermore, the four elements of CWEQ-II showed that HWCs believed they had moderate access to opportunity and information, with median (IQR) scores of 12 (1014) and 11 (9-12), respectively, and a low access to support and resources, with a score of 10 (912) and 9 (811), respectively. In addition, the median (IQR) total scores of DASS-21, MBI and CWEQ-II according to the HCWs who worked in the COVID-19 area or did not work in the COVID-19 area are presented in Fig.1A to C. According to these figures, the median (IQR) of total scores of DASS-21, MBI and CWEQ-II were significantly higher in the HCWs who worked in COVID-19 area.

Total scores of (A) DASS-21, (B) MBI and (C) CWEQ-II according to HCWs who worked in COVID-19 area or not were expressed as median (IQR)

The median (IQR) scores of the DASS-21, MBI and CWEQ-II scales were compared between the groups of HCWs who worked in the COVID-19 area or not. The results showed that the median score of anxiety (P=0.005), depression (P=0.040) and total score of DASS-21 (P=0.016), in HCWs who worked in the COVID-19 area were significantly higher than those who did not work in the COVID-19 area. Moreover, HCWs who worked in the COVID-19 area had a significantly higher median emotional exhaustion (P<0.001), depersonalization (P<0.001) and total score of MBI (P<0.001) compared to those who did not work in the COVID-19 area. In terms of CWEQ-II, HCWs who worked in COVID-19 areas had a significant higher score in opportunity (P<0.001).

Unadjusted and adjusted binary logistic regression analysis were conducted to determine potential predictors for the total scores of DASS-21, MBI and CWEQ-II. The results are presented in Figs. 2, 3, and4.

Unadjusted and adjusted binary logistic regression analysis of DASS-21 prognostic total scores. Forest plot showed results, after adjustingfor the factors: age, gender, having children, job position, working in COVID-19 area and history of mental health issues. In addition, a comparison of respondents' demographic variables based on high versus low-moderate DASS-21 scores is reported. Abbreviations; F/M: female/male; D/M: divorced/widowed/married; S/M: single/married, Y/N: yes/no; P/N: physician/nurse; T/N: therapist/nurse; O/N: others/nurse; I/A: internal medicine/anesthesiology; C/A: critical care/anesthesiology; S/A: surgery/anesthesiology; E/A emergency/anesthesiology; O/A others/anesthesiology; B/MD: bachelors-masters/ doctor of medicine; PhD/MD: doctor of philosophy/ doctor of medicine and OR: odds ratio

Unadjusted and adjusted binary logistic regression analysis of MBI prognostic total scores. Forest plot showed results, after adjusting forthe factors: age, gender, having children, job position, working in COVID-19 area and history of mental health issues. In addition, a comparison of respondents' demographic variables based on high versus low-moderate MBI scores is reported. Abbreviations; F/M: female/male; D/M: divorced/widowed/married; S/M: single/married, Y/N: yes/no; P/N: physician/nurse; T/N: therapist/nurse; O/N: others/nurse; I/A: internal medicine/anesthesiology; C/A: critical care/anesthesiology; S/A: surgery/anesthesiology; E/A emergency/anesthesiology; O/A others/anesthesiology; B/MD: bachelors-masters/ doctor of medicine; PhD/MD: doctor of philosophy/ doctor of medicine and OR: odds ratio

Adjusted binary logistic regression analysis for the prognostic value DASS-21 (Fig.2) showed that the divorced/ widowed HCWs (OR: 2.274, 95% CI: 1.0075.137, P=0.048), those working in internal medicine (OR: 2.077, 95% CI: 1.1573.726, P=0.014), those working more than 27h per week (OR: 1.723, 95% CI: 1.2322.411, P=0.001) and those with a history of mental illness (OR: 2.838, 95% CI: 1.3455.987, P=0.006) had a higher likelihood of experiencing stress, anxiety and depression in comparison to married HCWs, specifically those in anesthesiology, working27h per week, and those without history of mental illness, respectively. However, higher age (OR: 0.663, 95% CI: 0.1440.883, P=0.001) and higher work experience ofmore than 6years (OR: 0.562, 95% CI: 0.0880.899, P=0.008) were found to be negatively associated with the total score of DASS-21.

Adjusted binary logistic regression analysis for the prognostic value MBI (Fig.3) revealed that older HCWs (OR: 0.569, 95% CI: 0.0520.887, P=0.001) and those with higherwork experience of more than6years (OR: 0.585, 95% CI: 0.0520.802, P=0.007) had a lowerlikelihood of experiencing burnout compared to younger HCWs and those with less work experience. While, working longer than 27h per week (OR: 1.467, 95% CI: 1.1072.082, P=0.012), working more than 29h per week during the COVID-19 outbreak (OR: 1.358, 95% CI: 1.1252.035, P=0.046), working in COVID-19 area withinthe hospital (OR:1.782, 95% CI: 1.1282.225, P=0.004), directly interacting with COVID-19 patients (OR: 1.841, 95% CI: 1.1243.309, P=0.041), currently taking medication for mental illness (OR: 2.387, 95% CI: 1.1923.743, P=0.001) and having a family history of mental illness (OR: 1.969, 95% CI: 1.2263.161, P=0.005) were positively associated with burnout among HCWs.

Adjusted binary logistic regression was applied to the prognostic CWEQ-II (Fig.4), indicating that age (OR: 1.422, 95% CI: 1.1311.039, P=0.041), female gender (OR: 1.534, 95% CI: 1.1382.081, P=0.029), physicians (OR: 1.933, 95% CI: 1.3713.489, P=0.029), higher work experience (OR: 1.428, 95% CI: 1.1722.538, P=0.022), working in the COVID-19 area (OR: 2.371, 95% CI: 1.1684.809, P=0.017) and receiving specific training (OR: 1.546, 95% CI: 1.1332.109, P=0.006) were positively correlated with work effectiveness.

Unadjusted and adjusted binary logistic regression analysis of CWEQ-II prognostic total scores. Forest plot showed results, after adjusting forthe factors: age, gender, having children, job position, working in COVID-19 area and history of mental health issues. In addition, a comparison of respondents' demographic variables based on high versus low-moderate CWEQ-II scores is reported. Abbreviations; F/M: female/male; D/M: divorced/widowed/married; S/M: single/married, Y/N: yes/no; P/N: physician/nurse; T/N: therapist/nurse; O/N: others/nurse; I/A: internal medicine/anesthesiology; C/A: critical care/anesthesiology; S/A: surgery/anesthesiology; E/A emergency/anesthesiology; O/A others/anesthesiology; B/MD: bachelors-masters/ doctor of medicine; PhD/MD: doctor of philosophy/ doctor of medicine and OR: odds ratio

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Evaluation of psychological distress, burnout and structural empowerment status of healthcare workers during the ... - BMC Psychiatry

T Cells Formed During Omicron Breakthrough Infections Respond to Future Variants – Genetic Engineering & Biotechnology News

January 22, 2024

Breakthrough infections (infections after vaccination) by new variants of SARS-CoV-2 are common, despite the extensive immunization programs against SARS-CoV-2. Recent research suggests that human immune responses change in order to combat the never-ending emergence of new SARS-CoV-2 variants and studies point to memory T cells having a role in protecting individuals immunized with SARS-CoV-2 vaccines against variants.

Now, a team of South Korean scientists reveal that the memory T cells that form during Omicron breakthrough infections respond to subsequent strains of the virus.

This work is published in Science Immunology in the paper, Omicron BA.2 breakthrough infection elicits CD8+ T cell responses recognizing the spike of later Omicron subvariants.

This finding gives us new perspectives in the new era of COVID endemic, said Min Kyung Jung, PhD, research fellow at the Center for Viral Immunology, Korea Virus Research Institute, Institute for Basic Science (IBS). It can be understood that in response to constant emergence of new virus variants, our bodies have also adapted to combat the future strains of the virus.

The SARS-CoV-2 Omicron variant drastically increased transmissibility in comparison to its predecessors, which quickly allowed it to become the dominant strain in 2022. New strains (such as BA.1 and BA2, BA.4/BA.5, BQ.1, XBB, and more recently JN.1) of Omicron have emerged since then, leading to widespread breakthrough infection despite vaccination.

The research teams goal was to uncover the immune system changes that occur after post-vaccination breakthrough infections. Theytracked memory T cell responses in a cohort of vaccinated individuals in Korea who experienced BA.2 Omicron subvariant breakthrough infection in early 2022, focusing in on their ability to respond to various Omicron variants such as BA.2, BA.4/BA/5, and more.

The results showed that the memory T cells from these patients had heightened response against not only the BA.2 strain but the later BA.4 and BA.5 strains of Omicron as well. More specifically, they confirmed that BNT162b2 vaccination induced memory CD4+ and CD8+ T cells specific to BA.4/BA.5 spike, even if these individuals had a prior SARS-CoV-2 infection. Breakthrough infection with early Omicron subvariants (BA.1/BA.2) induced an increase in cross-reactive CD8+ T cell responses specific to BA.4/BA.5 spike.

In short, the breakthrough infection strengthened the patients immune systems to combat future variants. The research team also discovered the specific part of the spike protein that is the primary cause of the observed enhancement in the memory T cells. They wrote that they identified peptides in the BA.2 spike that were fully conserved in BA.4/BA.5 and later subvariants but absent in original spike.

These results show that once a person undergoes breakthrough infection by the Omicron infection, it is unlikely for them to suffer severe COVID-19 symptoms from the future emerging variants.

This new finding can also be applied to vaccine development, noted Eui-Cheol Shin, MD, PhD, professor at the Korea Advanced Institute of Science and Technology (KAIST) and director of the Center for Viral Immunology at the Institute for Basic Science (IBS). By searching for common features among the current dominant strain and emerging new strains of viruses, there may be higher chances to induce memory T cell defenses against the subsequent variants.

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T Cells Formed During Omicron Breakthrough Infections Respond to Future Variants - Genetic Engineering & Biotechnology News

Ron DeSantis wrong that boosters make COVID-19 infection more likely – Austin American-Statesman

January 22, 2024

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Ron DeSantis wrong that boosters make COVID-19 infection more likely - Austin American-Statesman

China ‘cloned’ COVID-like virus to test on mice, acknowledges ‘spillover’ risk to humans – Alabama’s News Leader

January 22, 2024

China 'cloned' COVID-like virus to test on mice, acknowledges 'spillover' risk to humans

by JACKSON WALKER | The National Desk

In this photo released by Xinhua News Agency, Yang Hongke checks on test samples at a testing lab of KingMed Diagnostics Group Co., Ltd. in Shijiazhuang in northern China's Hebei Province on Saturday, Jan. 9, 2021. (Mu Yu/Xinhua via AP) /{ }Closeup of Coronavirus COVID-19 computer generated image. (Getty Images)

WASHINGTON (TND)

Chinese researchers claim to have cloned a COVID-like virus mutation that showed a 100% mortality rate in mice.

In a report by researchers under a collaborative project between China and Mongolia, scientists explained the virus is a strain of coronavirus found in pangolins. They then cloned the virus and tested it on mice.

Each mouse tested on displayed symptoms of piloerection, hunched posture, and sluggish movements along with their eyes turning white and weight loss. They each died within eight days with late brain infection being the supposed cause.

Researchers continued, noting the infection could spillover to humans.

Infectious disease expert and University College London Professor Francois Balloux said via X that the study appears totally pointless.

I had a look at the preprint. It's a terrible study, scientifically totally pointless, Balloux wrote. I can see nothing of vague interest that could be learned from force-infecting a weird breed of humanised mice with a random virus. Conversely, I could see how such stuff might go wrong ...

Biologist Alex Washburne also noted the studys format as a letter to the editor raises further questions.

We also can't verify anything about the pre-print. The structure Dear Editor, ... raises questions about the provenance of the document (was it really written by the listed authors?) and the intentions of its release, Washburne said.

The U.S. Central Intelligence Agency offered hush money to analysts to cover up their findings that COVID-19 likely originated in a Wuhan, China laboratory, a whistleblower alleged in September. In February 2023, The Wall Street Journal reported that the U.S. Department of Energy concluded that COVID-19 originated in a Wuhan lab.

Other reports show that the Biden administration pressured Meta to suppress posts about the virus, including ones that theorized a lab leak theory.

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China 'cloned' COVID-like virus to test on mice, acknowledges 'spillover' risk to humans - Alabama's News Leader

When to come out of Covid isolation in 2023, according to experts – NBC News

January 22, 2024

Covid symptoms may change, but the appearance of a pink line on a rapid test means one thing for sure: five days of isolation.

The guidance, from the Centers for Disease Control and Prevention, has been in place since late 2021. At the moment, the agency doesnt appear to be making any changes to the policy.

But in some cases, telling people to isolate after a positive test may have an unintended effect.

Dr. Victoria Valencia, interim director for the Health Center for Student Care at Tulane University in New Orleans, said that she and her staff saw an uptick in Covid when students returned to campus in August. But that is no longer the case, as students now tend to decline Covid testing.

Students are afraid of being diagnosed with Covid because they dont want to isolate, Valencia said.

So is five days of isolation really best? Heres what experts say.

The current recommendation to isolate for five days is a hangover from when the CDC moved from a 10-day isolation recommendation to five days in late 2021, just as the first wave of omicron was taking hold in the U.S., said Harvard University epidemiologist Bill Hanage.

It was not a reflection of evidence-based science, he said. It was there to stop everything from falling apart.

At that time, a large chunk of the population was testing positive all at once because of the highly contagious variant. Recommending that everyone stay home and out of work for 10 days would have brought the country to a halt once again, so the five-day plan was put in place.

If you look at the safety of the public, and the need to have society not disrupted, this was a good choice, Dr. Anthony Fauci, former scientific adviser to the Biden administration, said at the time about the isolation recommendation.

There was also evidence that people are most contagious during those first five days of infection. That remains the most reliable scientific data, experts say.

We know that most people with Covid-19 shed enough virus that they are likely still contagious for at least five days, Jennifer Nuzzo, director of the Pandemic Center at Brown University School of Public Health, wrote in an email.

When the Covid public health emergency expired in May 2023, health officials in Oregon decided it was also time to pull back on the five-day isolation recommendation. Instead, the Oregon Health Authority suggested that people with Covid stay home only until theyve gone without spiking a fever for 24 hours and are generally feeling better.

In January of this year, California health officials issued the same guidance.

The ending of the public health emergency declaration doesnt change biology, Nuzzo said when Oregon changed its isolation recommendations. I dont see a biological reason to end the five-day isolation period.

People with the flu are most contagious the first three or four days after the illness begins, according to the CDC. People who test positive for influenza are advised to stay home until at least 24 hours after their fever is gone without the use of fever-reducing drugs, such as Tylenol.

A common cold virus is most contagious within the first few days but can continue to spread for up to two weeks, according to Johns Hopkins All Childrens Hospital research.

Like other viruses, people with Covid have varying degrees of sickness.

A set number of days to isolate is dumb if you think about it from a medical perspective, said Dr. Peter Chin-Hong, an infectious diseases specialist at the University of California, San Francisco.

If youre feeling fine the entire five days and have absolutely no symptoms, staying at home by yourself is not the same as somebody whos had symptoms and then after five days, theyre going out and coughing on everyone, Chin-Hong said. The symptoms approach makes more sense, not just for Covid, but for lots of other infectious diseases that people dont normally isolate for.

Saskia Popescu, an assistant professor of epidemiology and public health at the University of Maryland School of Medicine, said that while a persons risk of spreading Covid is in the first five days of infection, we know increasingly, that even without symptoms, or upon their resolution, people can still shed infectious virus.

Popescu said that means that while the risk is lower after Day 5, it doesnt mean theres zero risk. You should still try and stay home, she said. And if you absolutely need to, you can wear a mask.

Covid is a very unique infectious disease, Popescu added. Forty to 50% of cases are asymptomatic, or have such mild symptoms that people dont even realize they have symptoms.

In a study published in JAMA Pediatrics in October, researchers found that children ages 7 to 18 were infectious for a median of three days after a positive Covid test. By Day 5, the majority of the kids were no longer infectious.

My personal view is that five days is more than sufficient for isolation, said senior study author Neeraj Sood, a professor of health policy, medicine and business at University of Southern California. Based on the findings, maybe you could go with something a little shorter for kids.

An earlier study, published in the New England Journal of Medicine in July 2022, found that adults were infectious for a median of five or six days.

Popescu, who wasnt involved with either study, said the findings on children will probably be used moving forward for a lot of school-based decisions.

Its helpful to see the three days, Popescu said.

On an individual level, common sense should rule, Hanage said. If youre sick, stay away from people most at risk for severe complications, such as older relatives.

You wouldnt want to give them something that would make them badly ill whether its Covid, flu or even food poisoning, he said.

Popescu agreed.

From an infectious disease perspective, we want people to stay home if they have symptoms, she said. And just because you dont have Covid doesnt mean that you dont have another infectious disease that could pose a risk to those around you.

Dr. Michael Mina, an immunologist and former assistant professor of epidemiology at the Harvard T.H. Chan School of Public Health, urged people to do the best they can and take precautions where possible.

"Nobody's perfect," Mina said. "If you can decrease your chances of spreading to others, that's really good. That alone is very, very good. So if you can't isolate for five days, or it's been five days, but you recognize that you might still be infectious, wear a mask as much as you can, don't attend really densely packed events, and stay away from vulnerable people."

CORRECTION (June 12, 2023, 11:15 a.m. ET): A previous version of this article misstated Jennifer Nuzzos title and employer. She is director of the Pandemic Center at Brown University School of Public Health; she is not senior scholar at the Johns Hopkins Center for Health Security.

FollowNBC HEALTHonTwitter&Facebook.

Erika Edwards is a health and medical news writer and reporter for NBC News and "TODAY."

Akshay Syal, M.D.,is a medical fellow with the NBC News Health and Medical Unit.

Sara G. Miller is the health editor for NBC News, Health & Medical Unit.

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When to come out of Covid isolation in 2023, according to experts - NBC News

Coronavirus, mpox and rabies: A tale of three viruses – The Washington Post

January 22, 2024

Viruses are having a moment. Outbreaks around the world are on the rise, thanks to such factors as climate change, war and instability, and increased animal-to-human contact.

Covid-19 is still here. Even though fewer people are winding up in the hospital compared with last year, some health facilities are requiring masks again as a new variant appears better at infecting people, even those who are vaccinated. Meanwhile, across the globe, a deadlier strain of mpox is threatening the Democratic Republic of Congo, where lifesaving vaccines are difficult to obtain. In Nebraska, a kitten with rabies triggered an all-hands-on-deck public health response.

Post national health reporter Lena Sun has spent a lot of time trying to better understand pathogens and how they spread. She joins Post Reports to examine what lessons we have and havent learned from these three recent outbreaks, and what that means for preventing future ones.

Read more:

Another covid wave hits U.S. as JN.1 becomes dominant variant

Is this covid surge really the second largest?

Mpox surge in Congo raises concerns world will ignore warnings again

How one rabid kitten triggered intensive effort to contain deadly virus

Todays show was produced by Elana Gordon and hosted by Elahe Izadi and guest host Arjun Singh. It was mixed by Sean Carter and edited by Lucy Perkins. Thanks to Tracy Jan and Fenit Nirappil.

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Coronavirus, mpox and rabies: A tale of three viruses - The Washington Post

India Registers 25% Decline In COVID-19 Cases Even As JN.1 Infections Cross the 1,000 Mark | Weather.com – The Weather Channel

January 16, 2024

Representational Image

Monday, January 15: After five consecutive weeks of rising COVID-19 cases and anxieties, India finally witnessed a 25% dip in the viral infection during the week ending on January 13. And this encouraging trend was accompanied by a decline in deaths, with 22 reported compared to 31 the previous week.

As of Sunday, India logged 375 new cases of COVID-19, while the number of active infections has dropped to 3,075, the Health Ministry said. Although a new variant and colder weather conditions initially drove the surge, the situation now seems to be stabilising. The good news is widespread too, with most major states registering a drop in reported infections.

Kerala led the pack with a nearly 60% reduction, from 1,109 cases last week to 452 this week. Even Karnataka and Maharashtra, which were previously witnessing a surge, saw a gratifying decline. Karnataka, still with the highest case count at 1,583, had dropped from 1,856 previously, while Maharashtra reported a dip from 915 to 709.

Bengal remains a concern as it continues to see a rise in infections. But experts are closely monitoring the situation and urging strict adherence to safety protocols to prevent further spread.

While the recent developments offer a glimmer of hope amidst concerns about the new JN.1 sub-variant, a new INSACOG report indicates that we cannot let our guards down just yet.

According to INSACOG data, the JN.1 sub-variant has crossed the 1,000 mark nationwide. Karnataka has been revealed to be the leading hotspot with 214 cases, followed by Andhra Pradesh (189) and Maharashtra (170). Even as concerns remain about JN.1, official sources assure there's no evidence of it triggering an exponential increase in cases or a surge in hospitalisations and deaths.

Given the decrease in active COVID-19 cases, we do have reason for some cautious optimism. However, the JN.1 variant requires close monitoring, and continued vaccination efforts remain essential to bolster population immunity. Continued vigilance, coupled with responsible social distancing and adherence to safety protocols, can help solidify this downward trend and prevent future surges.

(With inputs from TOI)

**

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India Registers 25% Decline In COVID-19 Cases Even As JN.1 Infections Cross the 1,000 Mark | Weather.com - The Weather Channel

We Are in a Big Covid Wave. But Just How Big? – The New York Times

January 16, 2024

The curves on some Covid graphs are looking quite steep, again.

Reported levels of the virus in U.S. wastewater are higher than they have been since the first Omicron wave, according to data from the Centers for Disease Control and Prevention, though severe outcomes still remain rarer than in earlier pandemic winters.

We are seeing rates are going up across the country, said Amy Kirby, program lead for the C.D.C.s National Wastewater Surveillance System. The program now categorizes every state with available data at high or very high viral activity.

The surge might reach its peak this week or soon after, modelers predict, with high levels of transmission expected for at least another month beyond that.

Hospitalizations and deaths have remained far lower than in previous years. There were around 35,000 hospitalizations reported in the last week of December down from 44,000 a year earlier and 1,600 weekly deaths as of early December, down from 3,000. (At the same time in 2020, there were around 100,000 hospitalizations and 20,000 deaths each week.)

Many of the metrics used early in the pandemic have become much less useful indicators of how widely the virus is spreading, especially since federal officials stopped more comprehensive data tracking efforts when they declared an end to the public health emergency last spring. Higher population-wide immunity has meant fewer hospitalizations even with high virus spread, and the sharp decline of Covid test results reported to authorities has made case counts far less relevant.

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We Are in a Big Covid Wave. But Just How Big? - The New York Times

New COVID variant responsible for latest wave of infections – PBS NewsHour

January 16, 2024

Dr. Eric Topol:

Well, a lot more than it's doing.

In the first year of the pandemic, we saw that Operation Warp Speed, and we took this virus as an existential threat and pulled out all the stops.

But, right now, John, we need oral or nasal vaccines to stop infections, to stop spread, to be variant-proof, whatever this virus mutates to in the times ahead. And we have a small amount of funding towards that end, but not enough.

And the messaging has been poor. That is, even the people at highest risk, about 35 percent of them have had the updated booster that's been available since September. That's the highest-risk people of advanced age. We had 90, 95 percent of those same high-risk people getting the initial primary series of the vaccine.

So we're not doing enough. We have known this was coming. We have seen countries in Europe that had wastewater levels of the virus that were unprecedented, even exceeding Omicron. And it isn't like they stay the virus is going to stay there. We knew it was coming since September, October, and only in recent weeks have health systems started to get masking back as a policy.

We're just not doing enough to prepare or manage this big surge.

Read more:

New COVID variant responsible for latest wave of infections - PBS NewsHour

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