Category: Covid-19

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Study determines effectiveness of COVID-19 vaccination against Omicron variant in high-risk indoor settings – News-Medical.Net

February 28, 2022

The Omicron variant is the current dominant circulating strain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causal agent of coronavirus disease 2019 (COVID-19). The World Health Organization has classified the Omicron variant as a variant of concern (VOC) as a result of its higher virulence and transmissibility as compared to the original SARS-CoV-2 strain.

Study: Effectiveness of COVID-19 Vaccination Against SARS-CoV-2 Omicron Variant in Two Outbreaks in Indoor Entertainment Settings in Australia. Image Credit: View Apart / Shutterstock.com

In Australia, the SARS-CoV-2 Omicron variant was first detected among passengers who arrived on an inbound international flight in November 2021. Subsequently, a rapid surge in COVID-19 cases was reported, particularly in the most populous state of New South Wales (NSW).

Prior to the introduction of the Omicron variant in Australia, low and stable COVID-19 cases of five for every 100,000 due to the Delta variant were reported. An impressive COVID-19 vaccination was reported in Australia.

The first large outbreaks of the Omicron variant in Australia occurred in NSW, in the city of Newcastle. During this time, entertainment venues required attendees to provide evidence of completed primary COVID-19 vaccination; however, compulsory wearing of face masks or restrictions on the number of individuals were not implemented. Later, healthcare officials found that two of the four outbreaks were related to entertainment venues.

One outbreak occurred on December 8, 2021, wherein an individual with the Omicron infection attended a nightclub that was then open to the public. The nightclub consisted of several interlinked rooms with few windows, with common areas of an average size of 1000 square meters with approximately one person per 2.5 square meters at peak occupancy.

A second outbreak occurred due to the ball organized on December 10, 2021, for recently graduated medical students and medical school faculty at the Exhibition Centre. The exhibition hall was 1,195 square meters and was exclusively ventilated using air-conditioning.

A new study posted toPreprints with The Lancet / SSRNs First Look*estimates vaccine effectiveness against the SARS-CoV-2 Omicron variant in the aforementioned outbreaks in indoor entertainment settings in Australia. In this study, the scientists obtained the SARS-CoV-2 testing status of all individuals who attended each event and matched it to the Australian Immunization Register.

The authors classified these individuals based on having two or three valid doses of a COVID-19 vaccine. Furthermore, the researchers compared infection rates between the unvaccinated and vaccinated, in addition to estimating infection rate ratios and vaccine effectiveness.

A high force of infection was observed among mostly young adults with two doses of a COVID-19 vaccine. In the nightclub environment, two doses of widely administered vaccines, such as the Pfizer-BioNTech, Moderna, and Astra Zeneca vaccines, had poor effectiveness against the SARS-CoV-2 Omicron infection. These vaccines were administered at least two months prior to the event date.

In the medical graduation ball, two doses of COVID-19 vaccines were moderately effective, with higher vaccine effectiveness for more recent vaccine receipts. The number of booster recipients was small and scientists did not observe any incremental effect of the booster over two doses of the vaccine.

The current study analyzed unique outbreaks and vaccine effectiveness in crowded indoor environments where social restrictions were absent. The results suggest that public health measures are needed in such settings, in addition to requiring that attendees have received at least two doses of available COVID-19 vaccines.

Other recent studies from the United Kingdom, Denmark, and Canada showed poor effectiveness of two doses of current COVID-19 vaccines against the Omicron variant. Some studies have also shown that the booster dose restores some protection against SARS-CoV-2 infection, which has prompted many countries, including Australia, to reduce the time interval for booster doses following primary vaccination.

The findings in this study are in line with previous research; however, researchers did not identify a significant incremental contribution of the booster dose in reducing the risk of SARS-CoV-2 infection, which was an unexpected result. Owing to the young demographic, the researchers were not able to estimate vaccine effectiveness against hospitalization or severe disease. About 2-3% of infected individuals were presented to a hospital emergency in the two weeks following the outbreaks.

One limitation of the current study is the small number of individuals with no vaccination, which made it difficult to base the estimates of absolute vaccine effectiveness and generalize the results to all social contexts. Furthermore, the scientists had access to limited data on potential confounders, including reasons for receipt of booster doses.

Not all SARS-CoV-2 isolates in the current study were confirmed as the Omicron VOC. About 70% of those in each setting had either whole-genome sequencing (WGS) or the indicative spike gene target failure (SGTF) reported.

Preprints with The Lancet / SSRN First Look publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

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Study determines effectiveness of COVID-19 vaccination against Omicron variant in high-risk indoor settings - News-Medical.Net

The epidemiology of COVID-19 in Africa – News-Medical.Net

February 28, 2022

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the virus responsible for the coronavirus disease of 2019 (COVID-19), continues to spread across Africa, thus impacting mortality and morbidity rates on this continent. In fact, all 55 African Union (AU) Member States (MS) have reported COVID-19 cases, along with cases due to new SARS-CoV-2 variants, which have limited the efficacy of efforts to contain the pandemic.

However, since the majority of SARS-CoV-2 infections are either asymptomatic or mild, the true number of infections, along with age and sex distribution of infections, have not been fully determined yet in the context of Africa.

Study: Population-Based Serosurveys for SARS-CoV-2: Key Findings From Five African Countries: November 2020 to June 2021. Image Credit: Mukurukuru Media / Shutterstock.com

The number of confirmed COVID-19 cases that were detected and reported in each AU MS have been influenced by several factors such as the capacity for COVID-19 testing, case definition, access to and utilization of healthcare services, the manifestation of symptomatic illness among infected individuals, and community health-seeking behaviors.

National estimates of seroprevalence are considered to be important in understanding current or prior exposure to SARS-CoV-2 across populations, as well as to provide country-specific information for the development of guidelines for current and future control of epidemics. These estimates also help elucidate the true extent of the pandemic and provide insight into the factors that might have influenced transmission. Although previous seroprevalence studies have been carried out in Africa, they mostly focused on high-risk groups.

A new Preprints with The Lancet / SSRNFirst study Look* used the Africa Centres for Disease Control and Prevention (Africa CDC) generic protocol for obtaining COVID-19 seroprevalence data from Ethiopia, Uganda, Togo, Sierra Leone, and Zimbabwe to understand the spread and epidemiology of SARS-CoV-2 to help in response activities and guiding policies.

The current study recruited participants who filled out a questionnaire on pre-existing conditions, COVID-19 symptomology, basic demographics, pregnancy status, household information, hospitalization information, missed work or school, vaccination status, and treatments received. The survey varied in different countries and was conducted for varying durations from two weeks to two months between November 2020 and June 2021.

Blood samples were collected from the recruited participants and assessed for the presence of both immunoglobulin M (IgM) and IgG SARS-CoV-2 specific antibodies. Participants who showed the presence of either IgM, IgG, or both IgM and IgG were considered to be seropositive.

Out of the 31,707 individuals surveyed across the five AU MSs, the majority were female. The participants from Sierra Leone, Togo, and Uganda were five years and older, whereas the cohort in Zimbabwe consisted of participants who were one year and older, and in Ethiopia, study participants were ten years and older. The majority of participants were reported to be between 20 to 39 years old.

Most participants in Ethiopia and Sierra Leone lived in large households, while in Uganda and Zimbabwe the majority of participants lived in smaller households. Taken together, most of the participants resided in rural areas.

The highest overall weighted seroprevalence of SARS-CoV-2 antibodies was observed in Uganda, followed by Togo, while the lowest was observed in Sierra Leone. The risk of seropositivity also appeared to increase with age.

Seroprevalence was also found to be affected by several factors such as sex, occupation, and demographics, while symptoms, pre-existing medical conditions, and household size were not found to influence seroprevalence.

The current study determined that seroprevalence studies were important in providing public health leaders with important information for action against SARS-CoV-2. Variations in results from these five AU MSs suggest the need to regularly conduct serosurveys for better monitoring of the pandemic.

Some of the limitations of the current study included issues regarding inconsistent response options, missing data, and different sampling designs. Furthermore, the results were limited to the comparable variables, rather than the entire population. The observed levels of infection were also affected, as each MS implemented its survey according to local logistic factors.

Preprints with The Lancet / SSRN First Look publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.

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The epidemiology of COVID-19 in Africa - News-Medical.Net

Newark church celebrates COVID-19 resiliency with ‘Day of Hope and Healing’ – News 12 Bronx

February 28, 2022

Feb 27, 2022, 10:42pmUpdated 9h ago

By: News 12 Staff

Newarks Metropolitan Baptist Church held a special service calledDay of Hope and Healingto mark their accomplishment of getting their community tested and vaccinated.

Reverend Dr. David Jefferson, Sr. describes seeing people back in the pews as inspirational.

When we could see individuals coming back,walking down those pews, I have to tell you that was so heartwarming, says Jefferson.

The pastor described the last two years as devastating for the church. However, vaccination efforts through the Choose Healthy Life initiative have brought members back.

Choose Healthy Life addresses public health disparities and inequities in the Black community through the Black church.Founder Debra Fraser says thechurch is the one place where Black people gather to get information.

We had to go to the people that we trusted and have them reach out to the people in the community and bring the people in, says Fraser.

Sundays celebration is not just a celebration of testing and vaccinations for COVID-19. They are also celebrating a healthy life. Through Choose Healthy Life, they have addressed other medical issues that hurt the AfricanAmerican community at higher rates such as diabetes, hypertension and obesity.

We now have an army ready to deal with those things on the community level, says Fraser.

Members of the church were able to get tested and take at-home COVID-19 testing kits. Nine of the 120 churches across the country that participate in the initiative are located in Newark.

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Newark church celebrates COVID-19 resiliency with 'Day of Hope and Healing' - News 12 Bronx

When could COVID-19 become an endemic like the flu or common cold? – 11Alive.com WXIA

February 28, 2022

An endemic is where many hope COVID-19 is going. It means there's a low level of acceptable disease.

ATLANTA The U.S. Centers for Disease Control and Prevention relaxed mask guidance for about 70% of Americans Friday. That's left many people wondering could we be to the point of learning to live with the virus, similar to the flu or common cold?

The CDC said most people don't have to mask up if they live in areas where COVID-19 hospitalizations, hospital beds used, and cases are low to moderate.

The next step is to wait and watch," Dr. Richard Rothenberg said.

That's what Dr. Richard Rothenberg, a regents professor at the Georgia State University's School of Public Health, said the medical community will be doing.

There are three words pandemic, epidemic and endemic," Rothenberg said.

He said a pandemic is when a disease spreads over several countries or continents, and it affects a large number of people.

The World Health Organization declared COVID-19 a global pandemic on March 11, 2020.

As we speak of something as epidemic, we mean that it is on the upswing and we are experiencing a lot of disease," Rothenberg said.

An endemicis where many hope COVID-19 is going. It means there's a low level of acceptable disease.

The infection or whatever it is that we're talking about is embedded in the population," Rothenberg said. "It's there, and it can take a number of forms. It can just be constant throughout a period of time. It can be in increases that are often seasonal, such as influenza. It can die out and recur."

The WHO weighed in this week and said it's a gray area where COVID-19 goes from here.

Experts have recommendations on what you're encouraged to do once COVID-19 reached endemic levels.

It seems to me that the answer here is obvious for how to get out of this to get to an endemic stage. We can only vaccinate our way out of this pandemic," Dr. Paul Offit, a member of the FDA Vaccine Advisory Committee, said.

Rothenberg added that people who are older or who have underlying diseases may want to continue wearing their masks.

What we learned in the winter of 2021 was that if you wear masks, and a lot of people did for a long period of time, instead of 50,000 flu deaths, there were 200 during that season," Rothenberg said.

Those at the CDC encourage those who are more comfortable wearing to continue doing so.

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When could COVID-19 become an endemic like the flu or common cold? - 11Alive.com WXIA

COVID-19 has turned deadlier for Black Californians, who have the state’s lowest vaccination rate – Jefferson Public Radio

February 28, 2022

Deondray Moore sat in a plastic folding chair, rolled up his sleeve and got his first COVID-19 shot in the parking lot of Center of Hope Community Church in Oakland a week ago. He was the last in his family to get vaccinated after putting it off for more than a year, and only acquiesced because he wants to be in the delivery room when his son is born this summer.

My mom has been trying to get me vaccinated forever, since the (vaccines) came out, Moore said. My partner got it quick, and her kids got it as fast as they could. She wasnt playing around. She was like Dont miss out on the baby.

The 35-year-old Oakland native, an African American, knows multiple people who have contracted COVID-19 and died. Moore wears a mask and doesnt go out much. But hes suspicious of the vaccine and the way it was developed. I just dont trust the government, he said.

African Americans, who have a litany of historical reasons to mistrust public health officials and doctors, have the lowest vaccination rate in the state, at 55%.

COVID-19 has become deadlier for Black Californians since the widespread availability of vaccinations, and vaccine hesitancy could be among the reasons why. Other races, which have higher vaccination rates, have seen death rates rise, but not as dramatically.

A CalMatters analysis shows since last summer, the rate of Black Californians dying from COVID-19 has increased tenfold from one death per 100,000 people last July to 10.4 deaths this week. That surpasses Latinos and all races except Pacific Islanders, who are dying at the rate of 14.7 per 100,000, according to state data.

And while statewide deaths from COVID have declined in the past week, they have continued to rise for African Americans.

So far, 5,544 Black people have died from the virus in California.

Dr. Kim Rhoads, an associate professor of epidemiology at University of California, San Francisco, said she isnt surprised by the growing death rate among African Americans. Disparities arent new. They arent new to COVID, said Rhoads, who helped organize the community clinic where Moore got his shot.

For some Black residents, the disparity grew worse after vaccines became widely available last summer, according to a study from UC Santa Cruz and UC San Francisco researchers.

Middle-aged Blacks make up a growing, disproportionate share of the Californians who died, while the proportion shrank for Latinos and others: In March 2021, Black people aged 40-64, who make up roughly 5% of all middle-aged Californians, accounted for 6% of COVID-19 deaths in that age group. But a few months later, their numbers skyrocketed, accounting for 21% by last July, according to the study.

In contrast, middle-aged Latinos accounted for 66% of all COVID-19 deaths at the beginning of March 2021, but then last July shrank to 30%, mirroring their proportion of all middle-aged Californians.

Lead researcher Alicia Riley said preliminary data through November shows continuing disparities.

So why did the vaccines apparently help Latinos but not Black Californians? Its possible that those who are most at risk of dying from the disease arent getting vaccinated. Younger African Americans also may not have been included in early vaccination campaigns or may have felt they werent at risk of severe illness or death.

Whats puzzling to me is that they have a really different story in terms of whos dying, said Riley, a UCSC assistant professor of global and community health. Are the people who were at risk of dying in the Latino community actually being reached with vaccination, whereas somehow thats not happening for Black Californians as effectively?

ALICIA RILEY, UNIVERSITY OF CALIFORNIA, SANTA CRUZ

Experts say myriad other factors could also be driving the trend, including poverty, lack of insurance, distrust of the health care system and higher rates of health complications like diabetes or heart disease.

The increased share of deaths for Black Californians is a powerful sign of who was left behind when everyone else was kind of moving on out of the pandemic, Riley said.

The study did not find significant differences for other age groups, although state data suggests Black children fare worse than other races, too.

Black children in California are the second most likely to die from the virus among Californians younger than 18, with 1.2 deaths per 100,000 Black children. Pacific Islanders are twice as likely to die from COVID as Black children, while all other races have less than one COVID-19 death per 100,000 children.

The drivers for African American deaths are likely deeper than vaccination disparities.

Photo by Marissa Leshnov

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CalMatters

Rhoads, who studies death disparities in Black cancer patients, said pre-existing health complications also arent entirely to blame. Structural factors like poor quality health care also likely contribute to higher death rates, she said. For instance, medical devices like the pulse oximeter, which is used to determine whether a patient needs supplemental oxygen, dont work well on dark skin.

If we just say comorbidities, then were blaming the victim number one and were washing our hands of any responsibility, Rhoads said.

Vaccine campaigns successful for some

Substantial gains have been made among Latinos, according to Rileys study. After bearing the brunt in the early stages, Latinos death rate dropped from nearly 25 deaths per 100,000 people in January 2021 to 1 death per 100,000 in July. Over the last month, theCalifornia Department of Public Health estimates 7.2 Latinos died of COVID per 100,000 people, lower than the statewide rate of 8 per 100,000.

Around June 2021 the percentage of fully vaccinated Latinos outstripped Blacks and Native Americans, leaving Blacks in last place. Only 57% of Latinos are fully vaccinated, but some hard hit agricultural areas like Imperial County were quick to accept the vaccine and it has made a difference.

Eduardo Garcia, senior policy manager for the Latino Community Foundation, said high death rates among Latinos early in the pandemic galvanized local groups and clinics to dole out vaccines and combat misinformation.

Over 34,000 California Latinos have died since the beginning of the pandemic, Garcia said. It touched people close to home. I think that also created an impulse for people to get information from reliable sources and get the vaccine.

EDUARDO GARCIA, LATINO COMMUNITY FOUNDATION

Rhoads said refocusing COVID-19 vaccination messaging on preventing deaths rather than infections is important for equity, particularly since getting her community to trust the vaccine has been harder.

Its about a historical relationship between Black people and public health and health care, Rhoads said. Instead of saying lack of trust, Im saying theres no relationship there, so there should be no expectation of trust.

That trust was further shaken last spring when the Food and Drug Administration warned of rare but severe side effects associated with the Johnson and Johnson vaccine. Rhoads said the number of people seeking vaccinations at her clinic dropped precipitously.

To help bridge the gap, Rhoads founded Umoja Health, a collective of community and faith-based organizations in the Bay Area, to make COVID-19 testing and vaccination easy and accessible for African Americans. They bring pop-up clinic supplies to churches, schools and neighborhoods where they know vaccination rates are low. It takes patience and continued effort, Rhoads said.

Marissa Leshnov

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CalMatters

At Castlemont High School in Oakland, where the clinic frequently sets up shop, it was several weeks before many Black students trusted them enough to get the vaccine.

The Latino students came immediately, she said. But as weve been there over time, were starting to see more and more of the African American students come through, and then we started to see people bringing their parents.

Back to normal threatens Blacks and Pacific Islanders

Gov. Gavin Newsoms recent announcement that California would be moving into a new phase of the pandemic worries advocates and community health organizers like Rhoads.

The new state action plan acknowledges continuing disparities when it comes to COVID-19 deaths and highlights money in Newsoms budget that includes $819 million to expand Medi-Cal to undocumented individuals next year, $1.7 billion to invest in a more diverse health care workforce over five years and $65 million to fund the creation of an office of community partnerships and strategic communication.

But the plan offers little in terms of immediate action to fix disparities, and includes no specific programs to help Black communities.

The state health department on Thursday announced new $27 million contracts would be awarded to more than 100 community-based health organizations to shore up vaccination efforts in underserved communities, including African American ones.

However, community advocates worry that rhetoric used by Newsom like turning the page on the pandemic will ultimately prevent groups that have never caught up from moving forward.

We still have growing death rates and case rates. How can we move forward in the pandemic when were still suffering? said Karla Thomas, policy director for the UCLA Native Hawaiian and Pacific Islander COVID-19 Data Policy Lab.

Throughout the pandemic, Pacific Islanders have beenhit the hardest by COVID-19. Their mortality rate is nearly twice that of the statewide rate and nearly six times higher than the lowest rate of 2.5 deaths per 100,000 people among those who identify as multi-racial.

KARLA THOMAS, UCLA NATIVE HAWAIIAN AND PACIFIC ISLANDER COVID-19 DATA POLICY LAB

While data suggests that Pacific Islanders are nearly 100% vaccinated, Thomas said there is reason to believe that the states numbers are inaccurate. At times that number has creeped above 100%. From a personal experience, Thomas said she is one of only two people in her 50-person Samoan church in San Bernardino that she knows is vaccinated. Its not uncommon for there to be more than two funerals a month in her community.

Im really concerned that were not taking an equitable approach to mitigate the pandemic among (Native Hawaiian and Pacific Islander) communities and other communities of color, Thomas said. She criticized the lifting of the states mask mandate on Feb. 15 and the governors endemic plan.

Rhoads echoed Thomas sentiments.

The pandemic is not over. Its not for people who arent vaccinated, who dont have regular health care, she said.

Last week Rhoads and more than 35 organizations sent a letter to the state health department in part criticizing the states inconsistent and confusing messaging on masking. The health departments initial criteria for lifting the indoor mask mandate included vaccination and infection rates that were unmet when the mandate expired.

DR. KIM RHOADS, UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Rhoads said instances like this erode public trust in government and scientific organizations, particularly among groups that placed little faith in the institutions to begin with.

In response, the department agreed to schedule a meeting between Rhoads and State Public Health Officer Dr. Tomas Aragon.

In a separate response to CalMatters, the state health department said vaccine equity was the north star of its efforts to reach marginalized communities, and that it would continue to partner with community organizations, ethnic media, translators and faith-based groups.

This work is ongoing, and closing the equity gap across all California communities remains a priority to the states vaccination efforts, the department said in a statement.

Nothing to be afraid of

In Oakland at the Umoja clinic last week, George Dowell, a 40-year-old African American, said he was getting his second vaccination dose because he didnt want to be left behind as more and more businesses require proof of vaccination for entry.

Dowell is among the age group experiencing higher death rates in Rileys study. He spent the past year watching vaccinated friends and family carefully for side effects before deciding to get the shot himself.

Social media and misinformation played a role in Dowells hesitation. I was listening to certain people, social media, instead of listening to myself and doing whats right, Dowell said.

Three weeks ago, he decided it was time. He found the Umoja clinic while driving around the neighborhood and got his first Pfizer shot. Dowell wanted to show his school-aged nieces and nephews that there was nothing to be afraid of as they became eligible for the vaccine.

Dowells 27-year-old son is also unvaccinated, and Dowell said he promised he would call to let him know how he feels after this second shot

CalMattersis a nonprofit, nonpartisan media venture explaining California policies and politics.

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COVID-19 has turned deadlier for Black Californians, who have the state's lowest vaccination rate - Jefferson Public Radio

COVID-19 in Israel: Nearly 6,000 COVID cases recorded over weekend – The Jerusalem Post

February 28, 2022

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COVID-19 in Israel: Nearly 6,000 COVID cases recorded over weekend - The Jerusalem Post

Mass. Man Convicted of Fraudulently Seeking $13M in COVID-19 Loans – NBC10 Boston

February 28, 2022

A Massachusetts businessman has been convicted of fraudulently seeking more than $13 million in federal coronavirus pandemic relief loans.

Federal prosecutors say 40-year-old Elijah Majak Buoi, of Winchester, was convicted Thursday of wire fraud and making a false statement to a financial institution following a trial in Boston federal court.

Prosecutors say Buoi submitted six federal loan applications but misrepresented the number of employees and payroll expenses for his startup company.

They also say he submitted fraudulent IRS tax forms. Buois lawyer says his client was mislead by a bank loan officer and made a good faith mistake in completing the forms.

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Mass. Man Convicted of Fraudulently Seeking $13M in COVID-19 Loans - NBC10 Boston

Brooklyn’s Irving sees light at end of the tunnel as COVID-19 restrictions ease – Reuters

February 28, 2022

Feb 26, 2022; Milwaukee, Wisconsin, USA; Brooklyn Nets guard Kyrie Irving (11) reacts during a timeout in the fourth quarter against the Milwaukee Bucks at Fiserv Forum. Mandatory Credit: Benny Sieu-USA TODAY Sports

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Feb 27 (Reuters) - Brooklyn Nets guard Kyrie Irving said he was hopeful he would be able to finally play on his team's home court as New York moves to ease COVID-19 vaccination requirements amid falling case numbers.

Irving has refused to take the vaccine and as a result has been able to play only road games with the squad due to New York City's rule.

"The circumstances this year have not been ideal but I'm glad things are settling down and there's light at the end of the tunnel," Irving told reporters after the Nets' 126-123 win over the Bucks in Milwaukee on Saturday.

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"Hopefully I can get back on that home floor playing in Barclays and we can have a conversation about turning the page and moving forward beyond this."

Irving said he appreciated recent comments by NBA Commissioner Adam Silver, who said the city's mandate, which has kept Irving from playing home games but allows unvaccinated players from visiting teams to compete, "doesn't quite make sense to me".

"My respect for him went to a whole new level and I'm just grateful that he did that," Irving said of Silver. "He really took one for the team."

The NBA does not require its players to be vaccinated but Silver has strongly urged them to do so anyway. He has said that 97-98% of its players are vaccinated.

New York City Mayor Eric Adams, who took office on Jan. 1, has also been critical of the policy but has suggested a change to it is coming.

Irving scored a season-high 38 points on 14-for-26 shooting to upset the defending champion Bucks in a rematch of the 2021 Eastern Conference semi-finals.

It was Irving's first game in Milwaukee since he injured his right ankle in Game Four of that series at Fiserv Forum, ending his season.

"It definitely felt like there was a weight lifted being back here, being healthy, getting a win and knowing that there's a possibility we could see them down the line again," Irving said.

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Reporting by Rory Carroll in Los Angeles; editing by Clare Fallon

Our Standards: The Thomson Reuters Trust Principles.

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Brooklyn's Irving sees light at end of the tunnel as COVID-19 restrictions ease - Reuters

Will we always need Covid-19 booster shots to fight off virus? – The National

February 28, 2022

Almost two years after the new coronavirus caused the World Health Organisation to declare a pandemic, the world has racked up some impressive vaccination statistics.

One of them is that more than 1.27 billion booster doses have already been administered as governments look to strengthen the immunity of their citizens.

Typically a booster has been a third shot, although sometimes it has been a second if the initial vaccine was single-dose.

Fourth doses have already been administered in some nations, including Israel, where they were introduced in December for people with weakened immune systems, for healthcare workers and for the elderly.

It raises the question of whether boosters will be required indefinitely, perhaps to protect against new variants, or to bum up immunity that wanes over time.

Recent studies have indicated that after a third shot, people are able to produce a much wider range of antibodies than after just two doses. One piece of research looked at memory B cells, a type of white blood cell that produces antibodies.

After a third mRNA vaccine dose, scientists found that the antibodies produced showed significantly increased potency and breadth when compared to antibodies obtained after the second vaccine dose.

This is thought to be why a third dose increases protection against variants like Omicron which has numerous mutations distinguishing it from other variants even though the vaccines were not specifically designed to protect against variants.

Other research found that in people given some of the most popular Covid-19 vaccines, T cells, a type of immune cell often linked to durable protection against pathogens, were 80 per cent as effective against Omicron as they were against other variants.

This indicates that, thanks to T cells, the protection against Covid-19 generated by vaccination may be sustained even after antibody levels may decline.

Aside from looking at peoples immune response after two or three doses, researchers are also analysing the real-world effectiveness of multiple jabs at preventing disease.

A US study published on February 11 found that during the two months after a third dose of an mRNA (messenger RNA) vaccine, the jab was 91 per cent effective at stopping a person from requiring urgent care. But by the fourth month after the third dose, this had dropped to 78 per cent.

In response, Dr Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases and the chief medical advisor to the US president, said there may be the need for yet again another boost in this case, a fourth-dose boost for an individual receiving the mRNA [vaccine].

Speaking at the same time, he suggested this could depend upon a persons age and whether they have underlying conditions that make them more vulnerable to Covid-19.

Indeed the US and some other countries, such as the UK, now recommend a fourth dose for people with weakened immune systems.

A young woman receives a Pfizer jab in Diepsloot Township near Johannesburg, South Africa. AP Photo

While studies of B cells and T cells indicate the immunity may be durable in some people, information is limited by the fact that mass vaccination programmes began little more than a year ago (although some people on clinical trials were jabbed earlier).

The data just doesnt exist to say how the immunity will pan out, said Prof Ian Jones, a professor of virology at the University of Reading in the UK.

We simply dont know what the rate of decline will be after being boosted My guess would be for the coming year, certainly six months or 12 months, there will be detectable immunity in people whove received the booster.

That will be deemed sufficient for the next wave the standard [expected peak in] winter we have at the end of this year and beginning of next year.

Prof Nicolas Locker, professor of virology at the University of Surrey in the UK, said scientists can follow the immunity of people over a certain period and use the information gathered to predict how immunity will change later on.

But this, he said, was no substitute for following people for a year or two years, and it would not indicate what protection would be like against new variants.

A trial in Israel, details of which were released on Wednesday indicates that a fourth dose of an mRNA jab tops up a persons antibodies against Covid-19, but perhaps does not do much more than this.

The trial involved 274 healthcare workers given a fourth dose of either the Pfizer-BioNTech or Moderna jabs and compared them to hundreds of other people who were not administered the extra booster.

Researchers found that levels of neutralising antibodies (which can prevent the virus infecting human cells) increased after the fourth dose, but were not higher than amounts seen after a third jab.

So while a third jab has been shown to significantly boost protection, especially against new variants, a fourth may have a less significant effect, at least among healthy people whose immune systems already responded well to the third dose.

Also, even after the fourth dose, the vaccine had limited effectiveness at protecting a person from being infected with the coronavirus, although infections tended to be mild or asymptomatic rather then severe.

The researchers concluded that the low efficacy at preventing infections raise[s] the urgency of next-generation vaccine development.

A healthcare worker prepares to administer a Covid-19 vaccine in Mogadishu, Somalia. Reuters

There has been much discussion over whether repeated boosters will be needed to maintain protection against Covid-19.

Prof Paul Digard, chair of virology at the University of Edinburgh in the UK, said there probably wont be much call for a regular booster unless significantly different variants emerge.

Protection from virus infections and vaccination will give us some reasonable protection for a while. Im not expecting to be queuing up for a fourth booster in the next few months, he said.

Even if your antibody titres [concentrations] have waned enough that you can be reinfected, you still have memory response; you will be able to mount a good immune response faster and better.

Some experts, such as Prof Locker, think that governments may vaccinate populations periodically, as is the case against influenza in some countries.

In the long term, provided vaccine coverage is increasing, well probably move into a pattern of annual vaccination that covers us against circulating variants, he said. But this is only going to be efficient if we have good vaccine coverage worldwide.

Updated: February 28th 2022, 4:30 AM

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Idahos ongoing COVID-19 costs: $27.5 million for health care staff, and counting – Idaho Press-Tribune

February 28, 2022

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