Regenerons antibodies were studied in a clinical trial in outpatients in Arizona in 2020. Now, the Recoverystudy has found the therapy reduces mortality in some hospitalized patients with severe disease.
By Kai KupferschmidtJun. 16, 2021 , 1:00 AM
Sciences COVID-19 reporting is supported by the Heising-Simons Foundation.
The worlds largest trial of COVID-19 therapeutics has for the first time produced convincing evidence that a therapy that directly attacks the virus can save hospitalized patients from death. A combination of antibodies called casirivimab and imdevimab, produced by Regeneron, did not lower mortality when all patients in the study were taken together, investigators of the United Kingdoms Recovery trial announced todaybut it reduced deaths by one-fifth among those who did not produce antibodies themselves. A paper with the results will be made available on the medRxiv preprint server later today, the researchers say.
Here you have really the first direct SARS-CoV-2 drug, says Eric Topol, director of the Scripps Research Translational Institute. Two drugs previously shown to reduce mortality from COVID-19 were developed for other diseases and work by dampening an overactive immune response, which is kind of an indirect strategy, Topol says.
But Regenerons antibodies, which attach to the receptor-binding domain of the spike protein and prevent the virus from entering cells, are expensive and not widely available, and quickly identifying patients that benefit from it may be a challenge.
Researchers have developed several monoclonal antibodies against SARS-CoV-2, with mixed results. Some, including Regenerons, have shown some positive effects on disease progression in outpatients, but none was demonstrated to save the lives of severely ill patients in the hospital. The Recovery trial started to evaluate Regenerons cocktail in mid-September 2020. By late May, 9785 patients had been randomly allocated to receive either the usual care in the United Kingdom or the usual care plus a one-time infusion of the two antibodies, a procedure that takes roughly 1 hour.
About one-third of the patients were seronegative when they entered the trial, meaning they did not produce antibodies themselves. That includes people with underlying health conditions that weaken their immune system, but also people who, for unclear reasons, are unable to produce antibodies early on. In this group, 30% of patients given standard care died, versus 24% of those who received the antibody cocktail. That translates to six lives saved for every 100 such patients treated with the drug.
The Regeneron cocktail received a lot of attention when former U.S. President Donald Trump received it during his bout with COVID-19 in October 2020. Although its not clear whether Trumps immune system produced antibodies, the new results suggest the treatment may have helped save his life, Topol says: Who knows what might have happened at his age, with his morbid obesity and all the other risk factors that he had.
Although itreceived an emergency use authorizationfrom the U.S. Food and Drug Administration in November 2020and theU.S. government bought 1.5 million doses Regenerons therapy has not been widely used in the United States, Topol says. This is just sitting on shelves, he says. I think [the Recovery trial] is going to wake people up as to the benefit.
But doctors will have to determine which patients fail to produce antibodies. I think this isnt a complicated test to run, it just needs to be done, says Martin Landray of the University of Oxford, one of Recoverys principal investigators.
A bigger challenge may be cost. We anticipate, but we dont know this, that they may be around 1000 or 2000 per treatment, Recovery co-investigator Peter Horby said at a press conference on Tuesday. That might put the therapy and many similar ones in the pipeline out of reach for most people living in developing countries, which also have far fewer COVID-19 vaccine doses than rich countries. Access to antibody drugs in general has been particularly unequal across the globe, says Lindsay Keir, a pediatrician who co-authoreda Wellcome Trust report on global access to such treatmentsreleased last year. Antibodies that we have benefited from in high-income countries for 20, 30 years, still arent available in many countries, Keir says.
The inequity is a scandal, Horby says. There really must be an initiative to make these drugs accessible, and that requires two things: They have to be available, which means we have to scale up manufacturing, and they have to be affordable, which means we have to reduce the prices.
Follow this link:
Monoclonal antibodies cut risk of dying from COVID-19but only in some patients - Science Magazine
- USF epidemiologist: vaccination rate must double to slow transmission of COVID-19 - University of South Florida - July 24th, 2021
- Making waves in India: Media and the COVID-19 pandemic - Brookings Institution - July 24th, 2021
- COVID-19 cases increasing in King County: Vaccination continues to be our best protection - Public Health Insider - July 24th, 2021
- COVID-19 Daily Update 7-23-2021 - West Virginia Department of Health and Human Resources - July 24th, 2021
- New Zealand Suspends Travel Bubble With Australia As Sydney COVID-19 Cluster Grows - NPR - July 24th, 2021
- COVID-19: Are lockdowns worse than the disease? - Medical News Today - July 24th, 2021
- Alaska's COVID-19 surge continues with 447 cases, 2 deaths and rising hospitalizations reported Thursday and Friday - Anchorage Daily News - July 24th, 2021
- Oregon firefighters face return of hazardous conditions, COVID-19 outbreak - Reuters - July 24th, 2021
- We have vaccines. Did the Covid-19 Olympics have to be a mess? - Vox.com - July 24th, 2021
- Early COVID-19 responses in the nose and throat predict disease severity - Boston Children's Answers - Boston Children's Discoveries - July 24th, 2021
- Delta variant in Indiana: What you need to know about COVID-19 variant - IndyStar - July 24th, 2021
- COVID-19 town hall preps parents for return to school - The Mercury - July 24th, 2021
- Mayor Bowser and DC Health Release the District of Columbia COVID-19 Pandemic Health and Healthcare Recovery Report | mayormb - Executive Office of... - July 24th, 2021
- Breakthrough infection: Fully-vaccinated Struthers woman still contracted COVID-19 - WKBN.com - July 24th, 2021
- 1,000+ breakthrough cases of COVID-19 reported in Tennessee - WKRN News 2 - July 24th, 2021
- Illinois reports 7,983 new cases of COVID-19, 47 deaths over past week - WGN TV Chicago - July 24th, 2021
- Indias Covid-19 Death Toll Is Likely in the Millions, Study Finds - The Wall Street Journal - July 24th, 2021
- With Tokyo 2020 overshadowed by Covid-19, athletes are left to bring light to troubled Olympics - CNN - July 24th, 2021
- Gauteng launches COVID-19 vaccination drive-thru - SABC ... - July 22nd, 2021
- Grave concern: Gauteng prepares cemeteries as Covid-19 ... - July 22nd, 2021
- COVID-19: New maps expose Gauteng's worst hot-spots [photo] - July 22nd, 2021
- Texas has seen nearly 9000 COVID-19 deaths since February. All but 43 were unvaccinated people. - The Texas Tribune - July 22nd, 2021
- How Nations Are Learning to Live With Covid-19 Pandemic - The New York Times - July 22nd, 2021
- When will COVID-19 vaccines be fully approvedand does it matter whether they are? - Science Magazine - July 22nd, 2021
- Louisiana Hits Third-Highest Number Of COVID-19 Cases Reported In A Day - WWNO - July 22nd, 2021
- CBJ reports 29 new COVID-19 cases in Juneau July 20 & 21 City and Borough of Juneau - City and Borough of Juneau - July 22nd, 2021
- Who is providing COVID-19 care in the Washington Metropolitan Area? - The D.C. Policy Center - July 22nd, 2021
- COVID-19: What you need to know about the pandemic on 21 July - World Economic Forum - July 22nd, 2021
- COVID-19 cases going up in Oregon as number of people getting vaccinated drops - OPB News - July 22nd, 2021
- COVID Vaccines And Infertility? How Misinformation Spreads In 6 Steps : Shots - Health News - NPR - July 22nd, 2021
- Inslee rescinds three proclamations related to the COVID-19 pandemic | Governor Jay Inslee - Governor Jay Inslee - July 22nd, 2021
- Cape Cod COVID-19 cluster grows to more than 130 infected, prompting renewed mitigation efforts - ABC News - July 22nd, 2021
- COVID-19 Vaccine Success Could Be Measured With One Number - The Atlantic - July 22nd, 2021
- Delta Variant of Covid-19 Isnt Expected to Dent Robust U.S. Recovery - The Wall Street Journal - July 22nd, 2021
- How Universities Are Preparing for Another School Year Amid COVID-19 - WTTW News - July 22nd, 2021
- COVID-19: How can the air quality in India be improved? | World Economic Forum - World Economic Forum - July 22nd, 2021
- US extends Covid-19 travel restrictions with Canada and Mexico through August 21 - CNN - July 22nd, 2021
- Covid-19 'is becoming a pandemic of the unvaccinated,' CDC director says - CNN - July 20th, 2021
- Southeast Asian Countries Struggle To Contain A Devastating Third Wave Of COVID-19 - NPR - July 20th, 2021
- Covid-19 breakthrough infections are preventable, but it's going to take a big effort to stop them - CNN - July 20th, 2021
- Costco reverses course and will keep senior hours as COVID-19 cases increase nationwide - USA TODAY - July 20th, 2021
- U.S. Womens Gymnastics Alternate Tests Positive for Covid-19 at Tokyo Olympics - The Wall Street Journal - July 20th, 2021
- Olympics and Covid-19 pandemic: Live updates - CNN - July 20th, 2021
- ALERT: Uncontrolled COVID-19 spread reported in Williamson County - KXAN.com - July 20th, 2021
- Five Texas House Democrats test positive for Covid-19 in Washington - CNN - July 20th, 2021
- Austin area may see over 12,000 COVID-19 hospitalizations before October, UT projections show - KXAN.com - July 20th, 2021
- How Delta is pushing the US into a new phase of the Covid-19 pandemic - STAT - July 20th, 2021
- Baker-Polito Administration to Invest $186 Million in Federal COVID-19 Funding for Critical Health Care and Workforce Priorities - Mass.gov - July 20th, 2021
- COVID-19: What you need to know about the coronavirus pandemic on 19 July - World Economic Forum - July 20th, 2021
- NEW: Nevadas COVID-19 hospitalizations, cases soar as state hits 12% test positivity over the weekend - KLAS - 8 News Now - July 20th, 2021
- COVID-19 cases may cause an S&P 500 correction, analyst says. Buy these stocks in the next dip. - MarketWatch - July 20th, 2021
- VB health department hosting COVID-19 vaccine clinic on Wednesday, July 21 - WAVY.com - July 20th, 2021
- U.S. Covid-19 Case Counts Have Doubled in Recent Weeks - The Wall Street Journal - July 20th, 2021
- Insurer Filings Suggest COVID-19 Pandemic Will Not Drive Health Spending In 2022 - Kaiser Family Foundation - July 20th, 2021
- Vaccinated U.K. Health Secretary Tests Positive For COVID-19 - NPR - July 18th, 2021
- Music banned on Greece's Mykonos in new COVID-19 restrictions - Reuters - July 18th, 2021
- With Startling Surge in COVID-19 Cases Among the Unvaccinated, Gov. John Bel Edwards Encourages All Louisianans to Take Precautions - Governor John... - July 18th, 2021
- Niger Is the Land That Covid-19 Forgot - The Wall Street Journal - July 18th, 2021
- A small percentage of Alaska's COVID-19 cases have involved fully vaccinated people. Here's what we know so far. - KTOO - July 18th, 2021
- All adults in Britain offered a COVID-19 shot ahead of Monday reopening - Reuters UK - July 18th, 2021
- 154 Norovirus Outbreaks In England As Covid-19 Precautions Relaxed - Forbes - July 18th, 2021
- 'Just trying to keep it together': Springfield nurses frustrated as COVID-19 surges - News-Leader - July 18th, 2021
- From dancing to delta variant: One Austin mans COVID-19 battle and the message from his loved ones - KXAN.com - July 18th, 2021
- Louisiana Department of Health announces COVID-19 testing for week of July 19-25 | Department of Health | State of Louisiana - Louisiana Department of... - July 18th, 2021
- Georgia rugby coach on ventilator with COVID-19 in SAfrica - Associated Press - July 18th, 2021
- Here's How Well COVID-19 Vaccines Work Against the Delta Variant - Healthline - July 18th, 2021
- As COVID-19 surges again, what experts say about the millions of unvaccinated - ABC News - July 18th, 2021
- Yankees Add Aaron Judge and Two Others to Covid-19 Injured List - The New York Times - July 18th, 2021
- Clues to Covid-19s Origins Include Anonymous Skin Sample in Italy - The Wall Street Journal - July 18th, 2021
- COVID-19: Customer Information | Eastern Bank - July 15th, 2021
- 3 Things You Need to Know About the Delta Variant - COVID-19, Featured, Health Topics - Hackensack Meridian Health - July 15th, 2021
- COVID-19 Daily Update 7-15-2021 - West Virginia Department of Health and Human Resources - July 15th, 2021
- Massachusetts COVID-19 Relief Fund | Eastern Bank - July 15th, 2021
- Study finds physicians are widely effective messengers of Covid-19 information - MIT News - July 15th, 2021
- COVID-19 Delta variant could be to blame for recent breakthrough cases in fully vaccinated people - ABC Action News - July 15th, 2021
- CBJ reports nine new COVID-19 cases in Juneau July 13 & 14 City and Borough of Juneau - City and Borough of Juneau - July 15th, 2021
- COVID-19: What you need to know about the coronavirus pandemic on 15 July - World Economic Forum - July 15th, 2021
- COVID-19 pandemic leads to major backsliding on childhood vaccinations, new WHO - UNICEF - July 15th, 2021
- U.S. COVID-19 cases more than double in two weeks as delta variant spreads fast, and WHO warns 'pandemic nowhere near finished' - MarketWatch - July 15th, 2021
- Nearly in tears of disbelief: Central Texans share experiences of getting COVID-19 even after vaccination - KXAN.com - July 15th, 2021