The projection by the University of Washington's Institute for Health Metrics and Evaluation comes with a silver lining: About 70,000 of those lives would be saved if many more Americans wore masks, the institute's leader said.
"It really depends on what our leaders do, (both) as individuals, and what governments do," the IHME's chief, Dr. Chris Murray, told CNN's Anderson Cooper on Friday night.
IHME projected that if nothing about the nation's approach to prevention changed, death rates would dip in September but rise later in the fall, and the total would reach about 310,000 by December 1.
But changes in behavior would affect the projection, he said:
If governments ease current social distancing restrictions and mask mandates, daily death rates could reach 6,000 daily by December, up from his current prediction of 2,000 daily, Murray said.
On the other hand, if significantly more people wore masks, the projection of total deaths from now to December would drop by almost 70,000, he said. About 95% of the US population would have to wear masks for that to happen, he said.
Coronavirus case rates have been dropping for weeks in parts of the US, but death rates have been relatively elevated.
Daily US cases over the past week averaged about 44,100 as of Friday, down from a peak average of 67,317 on July 22, John Hopkins data show.
Preventing another wave
"We don't need to have a third wave in the heartland right now," Redfield said Thursday. "We need to prevent that."
On Friday, the top health official for Seattle and King County in Washington warned the state was seeing an increased number of cases linked to social gatherings.
"We expect Covid-19 to get worse in the fall and winter and people to spend more time indoors," said health officer Dr. Jeffrey Duchin.
To help prevent widespread infections, Murray said governors need to put mask mandates in place -- mandates "with teeth" -- that would allow local authorities to fine residents without a face covering.
"It will take a concerted effort but the impact is extraordinary, it's really quite extraordinary what it could achieve," Murray said.
6-year-old is Florida's youngest Covid-19 victim
Florida has reported more than 593,000 infections since the start of the pandemic, second only to California, which has recorded 660,000 positive results.
The girl's death comes as schools across the US have begun reopening. Some have adjusted plans after hundreds of students and staff were asked to quarantine in response to coronavirus cases.
More than two dozen cases linked to motorcycle rally
Minnesota reported 15 cases of the virus among people who attended the rally in South Dakota earlier this month, said Kris Ehresmann, infectious disease director at the Minnesota Department of Health.
Among those cases, one person was hospitalized. Officials say they expect more cases over the next few days.
In Nebraska's Panhandle region, at least seven cases were tied to the rally, according to Kim Engel, director of the Panhandle Public Health District.
Universities continue to struggle with reopening
In Florida, university officials are already identifying Covid-19 cases as students move into dorms, according to data from Florida universities.
Florida State University in Tallahassee has now created "a rapid COVID-19 test laboratory that turns around results in 24 hours" and its own contact assessment team, FSU spokeswoman Amy Farnum Patronis told CNN.
At Florida Atlantic University in Boca Raton, students began moving into campus dorms on a staggered schedule with designated hours to promote social distancing.
Mark and Kari Thronson from San Antonio, Texas, helped their freshman son, Tyler, move into his dorm on Friday. Kari Thronson told CNN's Natasha Chen she felt comforted by the university's protocols in place for their safety.
"I think it's everywhere. I don't think there's any hiding from it. I think just protecting yourself is the best thing you can do," Kari Thronson said.
Evania Lauscar, a freshman at Florida Atlantic who hopes to become a doctor one day, said she debated in July whether she would actually come to campus.
"I was thinking what if I do move in, and probably a week later or two, they tell us to go home? But I told myself I really want to be here and I kind of want to see this experience, so, so far it has been good, but it's still a thought in the back of my mind," Lauscar said.
Both Tyler Thronson and Lauscar said they have one course for which they need to attend in person, while the rest of the classes will be held remotely.
In other schools where students have moved in, university officials are working on limiting large group gatherings.
New students who say they plan to either host or attend parties will have their offers of admission rescinded, according to the letter from Madeleine Estabrook, the university's senior vice chancellor for student affairs. Current students can expect to be removed from university community, including the immediate loss of university housing, the letter said.
The university said it learned earlier this week that several students expressed on social media their intent to gather in large groups and to engage in parties.
Other colleges have already reversed plans for in-person classes and returned to remote learning after coronaviruses cases were detected on campus, leading to quarantines.
CNN's Melissa Alonso, Natasha Chen, Shelby Lin Erdman, Jennifer Henderson, Kay Jones, Jamiel Lynch, Janine Mack and Andy Rose contributed to this report.
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