Post-COVID dysautonomias: what we know and (mainly) what we dont know – Nature.com

Anand, H. et al. Nervous system-systemic crosstalk in SARS-CoV-2/COVID-19: a unique dyshomeostasis syndrome. Front. Neurosci. 15, 727060 (2021).

Article PubMed PubMed Central Google Scholar

Nagai, M., Kato, M. & Keigo, D. Anxiety and hypertension in the COVID-19 era: how is the central autonomic network linked? Hypertens. Res. 45, 922923 (2022).

Article CAS PubMed PubMed Central Google Scholar

Goldstein, D. S. Stress and the extended autonomic system. Auton. Neurosci. 236, 102889 (2021).

Article PubMed PubMed Central Google Scholar

Goldstein, D. S. Adrenaline and the Inner World: An Introduction to Scientific Integrative Medicine (Johns Hopkins University Press, 2006).

Davis, H. E., McCorkell, L., Vogel, J. M. & Topol, E. J. Long COVID: major findings, mechanisms and recommendations. Nat. Rev. Microbiol. 21, 133146 (2023).

Article CAS PubMed PubMed Central Google Scholar

Langley, J. N. The autonomic nervous system. Brain 26, 126 (1903).

Article Google Scholar

Cannon, W. B. & de la Paz, D. Emotional stimulation of adrenal gland secretion. Am. J. Physiol. 28, 6470 (1911).

Article CAS Google Scholar

Dale, H. H. & Feldberg, W. The chemical transmission of secretory impulses to the sweat glands of the cat. J. Physiol. 82, 121128 (1934).

Article CAS PubMed PubMed Central Google Scholar

von Euler, U. S. A specific sympathomimetic ergone in adrenergic nerve fibres (sympathin) and its relations to adrenaline and noradrenaline. Acta Physiol. Scand. 12, 7396 (1946).

Article Google Scholar

Goldstein, D. S. Principles of Autonomic Medicine v. 4.0 https://research.ninds.nih.gov/staff-directory/david-s-goldstein-md-phd (2020).

Goldstein, D. S. et al. Sympathoadrenal imbalance before neurocardiogenic syncope. Am. J. Cardiol. 91, 5358 (2003).

Article PubMed Google Scholar

Wallin, B. G. & Sundlof, G. Sympathetic outflow to muscles during vasovagal syncope. J. Auton. Nerv. Syst. 6, 287291 (1982).

Article CAS PubMed Google Scholar

Meck, J. V. et al. Mechanisms of postspaceflight orthostatic hypotension: low 1-adrenergic receptor responses before flight and central autonomic dysregulation postflight. Am. J. Physiol. Heart Circ. Physiol. 286, H1486H1495 (2004).

Article CAS PubMed Google Scholar

Davis, H. E. et al. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. EClinicalMedicine 38, 101019 (2021).

Article PubMed PubMed Central Google Scholar

Erdal, Y. et al. Autonomic dysfunction in patients with COVID-19. Acta Neurol. Belg. 122, 885891 (2022).

Article PubMed PubMed Central Google Scholar

Goldstein, D. S. The possible association between COVID-19 and postural tachycardia syndrome. Heart Rhythm. 18, 508509 (2021).

Article PubMed Google Scholar

Miglis, M. G., Stiles, L. E. & Raj, S. R. POTS may be underestimated in Post-COVID assessments. J. Am. Coll. Cardiol. 80, e103 (2022).

Article PubMed PubMed Central Google Scholar

Raj, S. R. et al. Long-COVID postural tachycardia syndrome: an American Autonomic Society statement. Clin. Auton. Res. 31, 365368 (2021).

Article PubMed PubMed Central Google Scholar

Stahlberg, M. et al. Post-COVID-19 tachycardia syndrome: a distinct phenotype of post-acute COVID-19 syndrome. Am. J. Med. 134, 14511456 (2021).

Article PubMed PubMed Central Google Scholar

Ormiston, C. K., Swiatkiewicz, I. & Taub, P. R. Postural orthostatic tachycardia syndrome as a sequela of COVID-19. Heart Rhythm. 19, 18801889 (2022).

Article PubMed PubMed Central Google Scholar

Mallick, D. et al. COVID-19 induced postural orthostatic tachycardia syndrome (POTS): a review. Cureus 15, e36955 (2023).

PubMed PubMed Central Google Scholar

Miglis, M. G. et al. A case report of postural tachycardia syndrome after COVID-19. Clin. Auton. Res. 30, 449451 (2020).

Article PubMed PubMed Central Google Scholar

Blitshteyn, S. & Whitelaw, S. Postural orthostatic tachycardia syndrome (POTS) and other autonomic disorders after COVID-19 infection: a case series of 20 patients. Immunol. Res. 69, 205211 (2021).

Article CAS PubMed PubMed Central Google Scholar

Gall, N. P., James, S. & Kavi, L. Observational case series of postural tachycardia syndrome (PoTS) in post-COVID-19 patients. Br. J. Cardiol. 29, 3 (2022).

PubMed PubMed Central Google Scholar

Johansson, M. et al. Long-haul post-COVID-19 symptoms presenting as a variant of postural orthostatic tachycardia syndrome. The Swedish experience. J. Am. Coll. Cardiol. Case Rep. 3, 573580 (2021).

Google Scholar

Parker, W. H. et al. COVID-19 and postural tachycardia syndrome: a case series. Eur. Heart J. Case Rep. 5, ytab325 (2021).

Article PubMed PubMed Central Google Scholar

Bosco, J. & Titano, R. Severe post-COVID-19 dysautonomia: a case report. BMC Infect. Dis. 22, 214 (2022).

Article CAS PubMed PubMed Central Google Scholar

Drogalis-Kim, D., Kramer, C. & Duran, S. Ongoing dizziness following acute COVID-19 infection: a single center pediatric case series. Pediatrics 150, e2022056860 (2022).

Article PubMed Google Scholar

Hanson, J., Richley, M., Hsu, J. J., Lin, J. & Afshar, Y. Postural orthostatic tachycardia syndrome and orthostatic hypotension in post-acute sequelae of COVID-19 during pregnancy: a case report. Eur. Heart J. Case Rep. 6, ytac453 (2022).

Article PubMed PubMed Central Google Scholar

Fanciulli, A. et al. Impact of the COVID-19 pandemic on clinical autonomic practice in Europe. A survey of the European Academy of Neurology (EAN) and the European Federation of Autonomic Societies (EFAS).Eur. J. Neurol. https://doi.org/10.1111/ene.15787 (2023).

Seeley, M. C., Gallagher, C., Langdon, A., Ong, E. & Lau, D. H. Postural orthostatic tachycardia syndrome is prevalent in postacute sequela of COVID-19? Clin. Auton. Res. 32, 368 (2022).

Google Scholar

Varma-Doyle, A., Freeman, R., Mandeville, R. & Gibbons, C. Neuromuscular and autonomic features in Long COVID-19: a single-center retrospective review of clinical and objective findings. Clin. Auton. Res. 32, 370 (2022).

Google Scholar

Hastie, C. E. et al. Outcomes among confirmed cases and a matched comparison group in the Long-COVID in Scotland study. Nat. Commun. 13, 5663 (2022).

Article CAS PubMed PubMed Central Google Scholar

Sharma, V., Pattnaik, S., Ahluwalia, H. & Kaur, M. Pre-pandemic autonomic function as a predictor of the COVID clinical course in young adults. Clin. Exp. Pharmacol. Physiol. 87, 594603 (2023).

Article Google Scholar

Sletten, D. M., Suarez, G. A., Low, P. A., Mandrekar, J. & Singer, W. COMPASS 31: a refined and abbreviated composite autonomic symptom score. Mayo Clin. Proc. 87, 11961201 (2012).

Article PubMed PubMed Central Google Scholar

Buoite Stella, A. et al. Autonomic dysfunction in post-COVID patients with and without neurological symptoms: a prospective multidomain observational study. J. Neurol. 269, 587596 (2021).

Article PubMed PubMed Central Google Scholar

Eldokla, A. M. et al. Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: a cross-sectional study. Ann. Clin. Transl. Neurol. 9, 778785 (2022).

Article CAS PubMed PubMed Central Google Scholar

Ser, M. H. et al. Autonomic and neuropathic complaints of long-COVID objectified: an investigation from electrophysiological perspective. Neurol. Sci. 43, 61676177 (2022).

Article PubMed PubMed Central Google Scholar

Larsen, N. W. et al. Characterization of autonomic symptom burden in long COVID: a global survey of 2,314 adults. Front. Neurol. 13, 1012668 (2022).

Article PubMed PubMed Central Google Scholar

Rinaldi, L. et al. Incidence of post-COVID-19 autonomic syndrome in working-age patients within 6 months from hospital discharge. Clin. Auton. Res. 32, 367 (2022).

Google Scholar

Bryarly, M., Cabrera, J., Tarpara, K., Barshikar, S. & Vernino, S. Minimal objective autonomic dysfunction in long-COVID. Clin. Auton. Res. 32, 362 (2022).

Google Scholar

Jamal, S. M. et al. Prospective evaluation of autonomic dysfunction in post-acute sequela of COVID-19. J. Am. Coll. Cardiol. 79, 23252330 (2022).

Article PubMed PubMed Central Google Scholar

Oakley, J. C. & Hendrickson, R. C. Central and peripheral hyperadrenergic symptoms significantly contribute to symptom burden in people with post-acute sequela of COVID-19. Clin. Auton. Res. 32, 366 (2022).

Google Scholar

Townsend, L. et al. Fatigue following COVID-19 infection is not associated with autonomic dysfunction. PLoS One 16, e0247280 (2021).

Article CAS PubMed PubMed Central Google Scholar

Chung, T. H. & Azar, A. Autonomic nerve involvement in post-acute sequelae of SARS-CoV-2 syndrome (PASC). J. Clin. Med. 12, 73 (2022).

Article PubMed PubMed Central Google Scholar

Shouman, K. et al. Autonomic dysfunction following COVID-19 infection: an early experience. Clin. Auton. Res. 31, 385394 (2021).

Article PubMed PubMed Central Google Scholar

Low, P. A. Autonomic nervous system function. J. Clin. Neurophysiol. 10, 1427 (1993).

Article CAS PubMed Google Scholar

Acanfora, D. et al. Impaired vagal activity in long-COVID-19 patients. Viruses 14, 1035 (2022).

Article CAS PubMed PubMed Central Google Scholar

Asarcikli, L. D. et al. Heart rate variability and cardiac autonomic functions in post-COVID period. J. Interv. Cardiovasc. Electrophysiol. 63, 715721 (2022).

Article Google Scholar

Marques, K. C. et al. Reduction of cardiac autonomic modulation and increased sympathetic activity by heart rate variability in patients with long COVID. Front. Cardiovasc. Med. 9, 862001 (2022).

Article CAS PubMed PubMed Central Google Scholar

Menezes Junior, A. D. S., Schroder, A. A., Botelho, S. M. & Resende, A. L. Cardiac autonomic function in long COVID-19 using heart rate variability: an observational cross-sectional study. J. Clin. Med. 12, 100 (2022).

Article PubMed PubMed Central Google Scholar

Mohammadian, M. & Golchoobian, R. Potential autonomic nervous system dysfunction in COVID-19 patients detected by heart rate variability is a sign of SARS-CoV-2 neurotropic features. Mol. Biol. Rep. 49, 81318137 (2022).

View original post here:

Post-COVID dysautonomias: what we know and (mainly) what we dont know - Nature.com

Related Posts
Tags: