Promising cancer vaccine in the works utilizing similar mRNA technology that combats COVID: Duke researchers – Fox News

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COVID-19 vaccine technology doesnt just fight viruses it can combat cancer.

Duke researchers find potential in a cancer vaccine based on the same messenger RNA, or mRNA, technology used by COVID-19 vaccines to combat a type of breast cancer that over expresses a protein called HER2, according to a recent Fox 8report.

"It is a product which is RNA nucleic acid which encodes a specific protein and then that can be encapsulated in something we like to call a lipid nanoparticle, which is really a little fat bubble, and that can be injected into your body and sort of teaches your body what to go after immunologically," said Dr. Zachary Hartman, assistant professor in the departments of surgery, pathology, and immunology at Duke University School of Medicine,

Hartman works in the lab at Duke thats spearheading the research.

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A healthcare worker administers a booster dose of a COVID 19 vaccine at a temporary vaccine center in Guatemala City, Tuesday, March 1, 2022. (AP Photo/Moises Castillo)

Dr. Herbert Kim Lyerly, who runs the lab, has been at Duke for almost 40 years, seeing first-hand how cancer therapy has evolved from chemotherapy, with its myriad side effects, to targeted immunotherapy, per the report.

"Think about that: in my career, a complete reversal of fortune for immunotherapy to be something to being considered an outsider, not likely to ever work, to being the most prominent form of cancer therapy and the development of new cancer therapeutics in the world, today," added Lyerly, George Barth Gellar professor of cancer research and professor of surgery, immunology and pathology at DukeUniversity.

According to Clinical CancerResearch, the HER2 protein, which is associated with aggressive tumor growth, goes on overdrive in 20% to 30% of breast cancers, so treatments are targeted against this protein, but drug resistance limits its use, said Lyerly.

So in 2019, the Duke researchers found potential in a phase 1 clinical trial with a vaccine that induced anti-tumor growth in seven of the 22 patients who had recurrent breast cancer, with two continuing to survive at the time of the published research, according to an updated July 9, 2019 pressrelease.

He told Fox News, "We have been working on this [vaccine mRNA] technology for many years. The COVID-19 pandemic highlighted the potency of the approach."

Although the current vaccine, which is a synthetic mRNA vaccine, is directed against breast cancer, it can be used for other cancers that express the HER2 protein, including lung cancer, stomach, and esophageal cancer, Lverly added.

An employee shows the Moderna COVID-19 vaccine at Northwell Health's Long Island Jewish Valley Stream hospital in New York, U.S., December 21, 2020. (REUTERS/Eduardo Munoz)

"Vaccines stimulate the immune system, specifically killer T cells, that now are active and react to seek and destroy tumor cells. It programs the immune system to not ignore the tumor cells, but to recognize them as bad guys to kill them," Lyerly told Fox News.

He assuages some peoples concern that mRNA technology can be harmful by explaining the context of how mRNA vaccines work in our body during the pandemic, per the newsoutlet.

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"You have mRNAs billions of mRNA copies in your body, right now. And so, to be concerned that the introduction of an mRNA coding of a viral protein is going to be harmful to you, again, doesnt make a lot of sense to me, because if you happen to be infected with a coronavirus, youre going to have a thousand times more mRNAs from the virus invading yourbody."

Vaccination is the best way to protect against COVID-19, he added, who disclosed to Fox News that he has equity in AlphaVax, a biopharmaceutical company that has patents on mRNA vaccines.

A person receives a COVID vaccine (Paul Hennessy/SOPA Images/LightRocket via Getty Images)

But although the studys vaccine works to a certain degree on its own against breast cancer, the tumor can recruit "backup strategies" to stay alive, according to a 2020 Duke pressrelease.

So the researchers are now in the part of the research that tests whether a new treatment works, called aPhase 2 trial, that combines the vaccine with an immune checkpoint inhibitor called pembrolizumab, which when used alone showed limited benefit against breast cancer but when combined with the vaccine, carries a "one-two punch," the press releaseadded.

"By working in tandem, the vaccine primes the immune system and the checkpoint inhibitor then rallies the T-cells to action, resulting in pronounced tumor reduction and long-term tumor-free survival," the press releasesaid.

"I think that within my lifetime we will see cancer as a more managed disease," saidHartman.

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"Were going to turn the dial and be able to treat more and more of these kinds of cancers in the coming years and decades to where its not quite the same sentence it was 20 or 30 years ago. I dont think well ever be able to rid the world of cancer, but I think we will be able to prevent a lot of cancers and then a lot of cancers that well be able to catch early and treat, well have very effective treatments."

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Promising cancer vaccine in the works utilizing similar mRNA technology that combats COVID: Duke researchers - Fox News