Category: Covid-19 Vaccine

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Examining COVID-19 Breakthrough Infections by Type of Vaccine Received – Contagionlive.com

April 16, 2022

COVID-19 vaccination, though highly effective against severe or fatal disease, does not offer full protection against infection. There are currently 3 vaccines available in the US: Pfizer-BioNTech (BNT162b2), Moderna (mRNA-1273), and Johnson & Johnsons-Janssen (JNJ-78436735). One study, presented this week at theSociety for Healthcare Epidemiology of America Conference 2022(SHEA), explored the demographic characteristics and disease outcomes of COVID-19 breakthrough infections by type of vaccine received.

The investigators included a total of 85 fully vaccinated patients with a documented COVID-19 breakthrough infection from February-September 2021. Breakthrough infection was defined as SARS-CoV-2 detection 14 days after receiving all initial doses of an authorized COVID-19 vaccine. The investigators collected patient demographics and hospitalization information, such as length of stay and oxygen needs.

Participants were recruited from 2 hospitals in Southeast Michigan, and classified by non-severe, severe, or critical disease. Patients were classified as severe if their oxygen saturation level was 94% on room air or if they required supplemental oxygen, and critical if they developed respiratory failure, including mechanical ventilation or extracorporeal membrane oxygenation.

A total of 85 breakthrough infections were identified in the study cohort. The average age of the patients was 69.9 years, and 51.8% were female. At 85.9% (n=73), severe disease was the most common type of breakthrough infection, followed by non-severe disease (n=7; 8.24%). A total of 9 (10.6%) deaths occurred in the cohort.

Most patients received the Pfizer-BioNTech (n=38; 44.7%) or Moderna (n=35; 41.2%) vaccine. Severe illness was more common among participants who received a Pfizer-BioNTech vaccination regimen (n=33/73; 45.2%), and patients with critical disease were more likely to have received the Moderna vaccine (n=4/5; 80.0%).

Moderna vaccine recipients had the longest time in between COVID-19 infection and vaccination (181.9 43.1 days) and Janssen vaccine recipients had the shortest time between testing positive and receiving the vaccine (91.0 61.1 days). The investigators concluded that COVID-19 breakthrough infections were uncommon among fully vaccinated persons, but increased with time after vaccination.

The study, SARS-CoV-2 Breakthrough Infections among Hospitalized Patients in Southeast Michigan, was presented on April 12 during theSociety for Healthcare Epidemiology of America Conference 2022(SHEA).

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Examining COVID-19 Breakthrough Infections by Type of Vaccine Received - Contagionlive.com

Beacon Health receives $4.8 million in grants for COVID-19 vaccine outreach – ABC 57 News

April 16, 2022

Beacon Health System has received $4.8 million in grants to provide education and other services to encourage vaccinations among Hispanic, Black, and Amish residents in St. Joseph, Elkhart, Marshall, and LaPorte counties.

The grant money, provided by the U.S. Health Resources and Services Administration, will be used to operate mobile vaccine clinics, hire additional non-clinical, bilingual community health workers, and create outreach efforts to educate residents about the vaccine.

The outreach is a collaboration with the Saint Joseph Health System and other community partners, such as public health departments and universities.

While COVID-19 numbers are trending in a direction that we are all excited to see, we want to be certain that everyone has the opportunity to make educated and informed decisions about vaccination, said Kimberly Green Reeves, Director of Community Outreach, Beacon Health System. We all must continue to do our part to remain healthy in our communities. It is important that we remain vigilant, especially now.

Residents interested in learning more about COVID-19 vaccines or where to find a vaccine clinic can visit CovidSmart.org for educational materials, video stories from local residents, and a calendar of clinics.

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Beacon Health receives $4.8 million in grants for COVID-19 vaccine outreach - ABC 57 News

Covid-19 Vaccines Carry Low Risk of Heart Conditions, Studies Find – The Wall Street Journal

April 16, 2022

The risk of developing inflammatory heart conditions after Covid-19 vaccination is relatively low, two large studies found, especially when compared with the heart-related risks from Covid-19 disease itself and from vaccines against other diseases.

One study, an analysis of 22 previous studies, found that the risk of the conditions including myocarditis in people who received a Covid-19 vaccine wasnt significantly different from that for non-Covid-19 vaccines such as those against flu, polio and measles. And the heart risk associated with Covid-19 shots was lower than the risk after smallpox vaccination. The results of the analysis, which included data on the effects of more than 400 million doses of various vaccines, were published online Monday by The Lancet Respiratory Medicine.

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Covid-19 Vaccines Carry Low Risk of Heart Conditions, Studies Find - The Wall Street Journal

OHA COVID-19 vaccination site will be moving to the Jackson County Expo – KDRV

April 16, 2022

MEDFORD, Ore. - The OHA COVID-19 vaccination site at the Merrick in Medford will be moving to the Jackson County Expo starting Thursday, April 21.

Tomorrow Saturday, April 16, will be the last day for COVID-19 vaccinations at the Merrick location. Starting this Thursday, April 21, the vaccination site will be move the the Jackson County Expo. The hours will be Thursday to Saturday from noon to 7 p.m. and Sunday from 11 a.m. to 4 p.m.

This will be a drive-through style vaccination site and you should plan on entering through gate 1.

Follow@KDRV12on Facebook and@KDRVon Twitter for the latest news, sports, and weather in Southern Oregon and Northern California.

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OHA COVID-19 vaccination site will be moving to the Jackson County Expo - KDRV

Promising cancer vaccine in the works utilizing similar mRNA technology that combats COVID: Duke researchers – Fox News

April 16, 2022

NEWYou can now listen to Fox News articles!

COVID-19 vaccine technology doesnt just fight viruses it can combat cancer.

Duke researchers find potential in a cancer vaccine based on the same messenger RNA, or mRNA, technology used by COVID-19 vaccines to combat a type of breast cancer that over expresses a protein called HER2, according to a recent Fox 8report.

"It is a product which is RNA nucleic acid which encodes a specific protein and then that can be encapsulated in something we like to call a lipid nanoparticle, which is really a little fat bubble, and that can be injected into your body and sort of teaches your body what to go after immunologically," said Dr. Zachary Hartman, assistant professor in the departments of surgery, pathology, and immunology at Duke University School of Medicine,

Hartman works in the lab at Duke thats spearheading the research.

EAST COAST COVID-19 CASES ON THE RISE

A healthcare worker administers a booster dose of a COVID 19 vaccine at a temporary vaccine center in Guatemala City, Tuesday, March 1, 2022. (AP Photo/Moises Castillo)

Dr. Herbert Kim Lyerly, who runs the lab, has been at Duke for almost 40 years, seeing first-hand how cancer therapy has evolved from chemotherapy, with its myriad side effects, to targeted immunotherapy, per the report.

"Think about that: in my career, a complete reversal of fortune for immunotherapy to be something to being considered an outsider, not likely to ever work, to being the most prominent form of cancer therapy and the development of new cancer therapeutics in the world, today," added Lyerly, George Barth Gellar professor of cancer research and professor of surgery, immunology and pathology at DukeUniversity.

According to Clinical CancerResearch, the HER2 protein, which is associated with aggressive tumor growth, goes on overdrive in 20% to 30% of breast cancers, so treatments are targeted against this protein, but drug resistance limits its use, said Lyerly.

So in 2019, the Duke researchers found potential in a phase 1 clinical trial with a vaccine that induced anti-tumor growth in seven of the 22 patients who had recurrent breast cancer, with two continuing to survive at the time of the published research, according to an updated July 9, 2019 pressrelease.

He told Fox News, "We have been working on this [vaccine mRNA] technology for many years. The COVID-19 pandemic highlighted the potency of the approach."

Although the current vaccine, which is a synthetic mRNA vaccine, is directed against breast cancer, it can be used for other cancers that express the HER2 protein, including lung cancer, stomach, and esophageal cancer, Lverly added.

An employee shows the Moderna COVID-19 vaccine at Northwell Health's Long Island Jewish Valley Stream hospital in New York, U.S., December 21, 2020. (REUTERS/Eduardo Munoz)

"Vaccines stimulate the immune system, specifically killer T cells, that now are active and react to seek and destroy tumor cells. It programs the immune system to not ignore the tumor cells, but to recognize them as bad guys to kill them," Lyerly told Fox News.

He assuages some peoples concern that mRNA technology can be harmful by explaining the context of how mRNA vaccines work in our body during the pandemic, per the newsoutlet.

2021 DEADLIEST YEAR IN US HISTORY DUE TO COVID-19, DRUG OVERDOSES

"You have mRNAs billions of mRNA copies in your body, right now. And so, to be concerned that the introduction of an mRNA coding of a viral protein is going to be harmful to you, again, doesnt make a lot of sense to me, because if you happen to be infected with a coronavirus, youre going to have a thousand times more mRNAs from the virus invading yourbody."

Vaccination is the best way to protect against COVID-19, he added, who disclosed to Fox News that he has equity in AlphaVax, a biopharmaceutical company that has patents on mRNA vaccines.

A person receives a COVID vaccine (Paul Hennessy/SOPA Images/LightRocket via Getty Images)

But although the studys vaccine works to a certain degree on its own against breast cancer, the tumor can recruit "backup strategies" to stay alive, according to a 2020 Duke pressrelease.

So the researchers are now in the part of the research that tests whether a new treatment works, called aPhase 2 trial, that combines the vaccine with an immune checkpoint inhibitor called pembrolizumab, which when used alone showed limited benefit against breast cancer but when combined with the vaccine, carries a "one-two punch," the press releaseadded.

"By working in tandem, the vaccine primes the immune system and the checkpoint inhibitor then rallies the T-cells to action, resulting in pronounced tumor reduction and long-term tumor-free survival," the press releasesaid.

"I think that within my lifetime we will see cancer as a more managed disease," saidHartman.

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"Were going to turn the dial and be able to treat more and more of these kinds of cancers in the coming years and decades to where its not quite the same sentence it was 20 or 30 years ago. I dont think well ever be able to rid the world of cancer, but I think we will be able to prevent a lot of cancers and then a lot of cancers that well be able to catch early and treat, well have very effective treatments."

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Promising cancer vaccine in the works utilizing similar mRNA technology that combats COVID: Duke researchers - Fox News

COVID-19 vaccines will not be required for school entry in Washington state – The Spokesman Review

April 14, 2022

The Washington State Board of Health will not require COVID-19 vaccines for children to attend schools and day cares.

Earlier this year, the technical advisory group, made up of representatives from public health and education sectors statewide, had recommended that the board not require the COVID vaccine for school entry after considering nine criteria, studying the data and collecting input from experts.

That group concluded that the vaccine was safe and effective at preventing disease, and reducing the risk of transmission.

The group disagreed about whether the vaccine was cost effective and how a requirement might be a burden to comply with, and members had worries over public sentiment. It was for these reasons that the technical advisory group voted to not recommend the COVID vaccine be required for students. The vaccine is required for most teachers and child care workers in Washington.

Ultimately, the board agreed with their advisory group.

Board members said their decision is not a signal that vaccines are not effective against the virus.

The Department of Health very much supports the safety and effectiveness of COVID-19 vaccinations, and particularly, its been shown to prevent severe disease, hospitalizations and death, and we believe its safe and effective in all populations, Secretary of Health Dr. Umair Shah said on Wednesday.

But while board members agreed the vaccine is safe and effective, they also acknowledged that contending with public sentiment and the burden of compliance were too great.

Board members wanted to see some data that is not yet available, including studies showing how vaccines affect virus transmission in schools or how vaccinated children can bring down COVID hospitalization rates.

School districts across the state, as well as their representatives on the technical advisory group, expressed concerns about the work that would be necessary to enforce a newly mandated vaccine in the schools, especially when exemptions are accepted and must be processed. Some Board of Health members expressed support for increasing resources for school nurses and districts to be able to serve their students as a result.

Additionally, some parents, including some of those publicly commenting on Wednesday, threatened to pull their children out of public schools should a COVID vaccine mandate go into effect.

The effectiveness of a mandate in Washington state schools was also questioned Wednesday, especially with a survey from the Kaiser Family Foundation showing 28% of parents surveyed would definitely not vaccinate their children, with just 4% of that group saying a vaccine requirement would change their mind.

Even the Washington Chapter of the American Academy of Pediatrics did not endorse a COVID vaccine requirement for students.

Dr. Michael Barsotti, president of the chapter, told the Board he believes all children and teens should be vaccinated, but keeping kids in school is also a priority.

If the priority is for in-person school attendance, the vaccine mandate would create barriers to achieving that goal, Barsotti told the Board.

Equitable distribution of the vaccine and access to the vaccine was also a concern among board members, pointing to low vaccination rates among Hispanic and Black children in the state.

The board received thousands of public comments, both written and verbal, opposing the mandate of the COVID vaccine in schools.

During his 11-year tenure on the board, President Keith Grellner said he cannot recall a time when there was so much public response and reaction to the boards potential actions. And while people protesting vaccine mandates is nothing new, Grellner said the pandemic has been completely different.

Its nothing like what weve had the last year and a half or two years its nothing the scope, the depth, the intensity, this is warp-speed above anything else weve dealt with, Grellner said.

Earning back the publics trust was top of mind for board members.

We have to rebuild that trust and be able to show the residents we dont have enough information, but were willing to put this on pause until we have more information to make a more data-driven decision, said Elisabeth Crawford, who represents cities on the Board of Health.

The board also left open the door to revisit requiring the COVID vaccine in schools in the future if its necessary due to a new variant or more severe disease in children.

The Board of Health alone has the authority to require vaccinations for students for entry to day cares and schools in Washington state.

It has a multistep process to go through each time they consider requiring an additional vaccine in Washingtons schools, and board members praised the transparent process on Wednesday.

If science changes in the future, this recommendation might also change, said Dr. Tao Kwan-Gett, chief science officer at the Department of Health.

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COVID-19 vaccines will not be required for school entry in Washington state - The Spokesman Review

Baker-Polito administration encourages COVID-19 vaccination and boosters at family-friendly events during April school vacation week – Mass.gov

April 14, 2022

Boston The Baker-Polito Administration is partnering with local businesses across the state to host free, family-friendly COVID-19 vaccination clinics and offer giveaways for getting vaccinated during April school vacation week, April 18-22. With the support of the Massachusetts Department of Public Health (DPH), these clinics will be held in 10 cities and towns at various locations, including trampoline parks, zoos, bowling alleys, and the Six Flags New England amusement park, to encourage a family-friendly atmosphere in which eligible individuals of all ages can get vaccinated and boosted.

The clinics build on the success of vaccination clinics held earlier this year during February school vacation week, when more than 2,000 vaccinations were administered to children and adults in communities most disproportionately impacted by COVID-19.

The clinics are part of DPHs Vaccine Equity Initiative to increase awareness and access to the COVID-19 vaccine and mitigate the impacts of the pandemic among the hardest-hit populations and communities.

The best protection from COVID-19 infection remains vaccination and staying updated on all of the vaccine doses you are eligible for, said Public Health Commissioner Margret Cooke. These events are a convenient way for the whole family to get up to date on COVID-19 vaccinations, and we thank the businesses and local partners for joining us to offer vaccination at these family-friendly locations.

At participating locations, individuals receiving a first or second vaccine or a booster dose will receive a giveaway such as free admission tickets or an hour of trampoline or bowling time, depending on the specific location. In a special partnership with Six Flags, any Massachusetts resident who gets vaccinated at the Six Flags clinic will receive two admission tickets, free parking, and a meal.

April Vacation Family Clinics:

Municipality

Location

Schedule

Giveaway

Everett

Everett City Clean Up Day @ Rivergreen Park

April 23

$25 gift card

Lawrence/ Methuen

1 Broadway Street, Methuen

April 21-April 24

$25 gift card, prizes and ice cream

Malden

Mixer eSports Cafe

April 22-24

1 hour of free game play

Swansea/ Fall River

Get Air Trampoline Park (Parking Lot)

April 21-23

1 hour of free jumping

New Bedford

Buttonwood Park Zoo (Parking lot)

April 23 and 24

2 free entry passes

New Bedford

Wonder Bowl

April 22 and 23

1 hour of free bowling

Springfield

Eastfield Mall

April 20

$25 grocery gift card, free food, music and games

Springfield

Bounce! Trampoline Park

April 21

1 hour of free jumping

Springfield

Interskate 91

April 22

1 hour of free skating

Agawam and Western MA

Six Flags

April 22, 23, and 24

2 free entry passes + free parking and 1 free meal, snack, and drink (MA residents only)

Brockton

FunZ Trampoline Park

April 21-23

1 hour of free jumping

Brockton

Arnone School

April 19-22

$25 grocery gift card

Lowell

Khmer New Year Celebration, Clemente Park

April 23

$25 grocery gift card

Lowell

Nibbana Caf

April 23 and 24

$25 Nibbana gift card

Chelsea

Playground and Archery Games@ Boston Playground

April 20, 21, and 22

1 hour of free play voucher

Massachusetts leads the nation in COVID-19 vaccine administration, with over 82% of eligible residents (5+) fully vaccinated, and over 53% of eligible residents (12+) having received a booster.The best way to protect against severe illness from COVID-19 is to get vaccinated and boosted and remain up to date on shots.

To see a full list of these special clinics and giveaways, visit http://www.mass.gov/KidsClinic.

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Baker-Polito administration encourages COVID-19 vaccination and boosters at family-friendly events during April school vacation week - Mass.gov

New COVID-19 vaccine study challenges stereotypes of who is getting the shots – The Boston Globe

April 14, 2022

Overall, the researchers found that stark disparities in vaccine and booster coverage persist in the state, leaving thousands vulnerable to severe illness as increasingly more transmissible forms of the virus circulate.

Despite a lull in COVID-19 infection rates, MA is in a precarious position, they wrote.

In the study, which was posted online Monday but not yet published in a peer-reviewed journal, the team analyzed state data on residents vaccinated and boosted by ZIP code through March 1. They also examined census-tract population estimates and ZIP-code-level socioeconomic and demographic data, including education level, household income, and profession.

When the researchers took education and age into account, they found that many communities with large concentrations of Black and Latino residents and essential workers had higher levels of vaccination than similar communities with many white residents and fewer essential workers.

For example, consider the towns of Randolph and Dartmouth. Both are south of Boston and have residents with similar age distributions and college graduation rates of roughly 27 percent. In Randolph, where Black and Latino residents make up about 53 percent of the population, 81 percent of the town had been vaccinated. Yet in Dartmouth, where 8 percent of residents are Black or Latino, just 60 percent of the community had been vaccinated.

This is not to say that race doesnt matter, said Jacob Bor, an assistant professor in epidemiology and global health at Boston Universitys School of Public Health and lead author of the study.

Race, ethnicity, age, and education levels overlap, he said. The team found that communities of color and those with a lot of essential workers are, on average, younger and have lower levels of education and lower incomes, which can affect peoples access to the shots.

These differences in income and education among Black, Latino, and Indigenous populations are a product of longstanding patterns of differential access to education, wealth, and opportunity, Bor said.

Income, the team found, was also a strong predictor of vaccination coverage. A $10,000 increase in a ZIP codes median household income was associated with higher vaccination and booster rates. From the lowest to the highest income levels, booster coverage increased from under 30 percent to over 60 percent.

Our analysis shows that education and income are better explanations for the patterns than race or ethnicity itself, said Dr. Jonathan Levy, who chairs the department of environmental health at BUs School of Public Health, and is senior author of the research.

But despite high, relatively equitable coverage for the original vaccine schedule in adults, researchers found large inequities in rates among children, and very large inequities for booster shots in all age groups.

In ZIP codes with the highest share of college-educated residents, about 70 percent of children have been vaccinated. Conversely, less than 40 percent of children have been vaccinated in the 10 percent of ZIP codes with the lowest percent of college educated residents, including those with the highest percentages of Black, Latino, and Indigenous populations.

We must redouble our ongoing efforts to overcome barriers related to poverty and education like collaborating with community partners who offer vaccination outside of health care venues, after hours, and on weekends, and provide clear and accurate information from trusted sources, said Dr. Bisola Ojikutu, Bostons Commissioner of Public Health, and a coauthor of the study.

The only way to address this inequity, she said, is through persistence.

Disparities were also pronounced when looking at who has received at least one booster shot, and controlling for education and age levels did not change that picture as it did for the primary vaccine series. The share of residents 65 and older who have received a booster was just over 50 percent in ZIP codes with the lowest share of college graduates and highest share of Black, Latino, or Indigenous people, the researchers found. Yet booster coverage was over 70 percent in more-educated ZIP codes and those with larger White populations.

A better understanding of the causes of the disparities should help policy makers address them, experts said.

This report highlights that people with complicated lives, and a lot of folks stereotyped as being hesitant, actually had high vaccination rates. And it really points to this being an access issue and we have to be better, said Atyia Martin, executive director for Next Leadership Development, a nonprofit that focuses on building resilience in Black communities.

While vaccines have been widely offered in local pharmacies and doctors offices, Martin and others said many lower-income essential workers often lack the transportation or time off, particularly if they suffer side effects after getting vaccinated.

We have to have strategies that are more sophisticated and account for peoples real lives and what theyre dealing with, Martin said. And we have to let the data be the guide for the decisions we are making.

The researchers suggested that strategies used successfully during the initial vaccine rollout, such as establishing more convenient places and times for essential workers to get the shots, should be widely extended for boosters. They also said Massachusetts should especially target this push in lower-educated communities, regardless of racial composition.

Brennan Klein, a post-doctoral researcher at Northeastern University who has studied COVID and racial biases, said the researchers careful statistical approach . . . offers [state policy leaders] a nice road map for how to direct vaccination efforts moving forward.

Nadia Abuelezam, an associate professor who specializes in biostatistics and health inequities at the Connell School of Nursing at Boston College, said the study offers very specific geographic information down to the ZIP code level for fine tuning public messages in future vaccination initiatives.

It allows us to think about where people live, work, and play, and how that influences their health, she said.

Michael Curry, chief executive of the League of Community Health Centers, was struck by the strong correlation the researchers found between education level and vaccination status. And he said that policy leaders, as well as health providers need to use that finding to guide ongoing and future vaccination efforts.

We have got to stop relying on people having a college degree or high school diploma to get what they need to make decisions on their health, he said.

We need employers to be in lockstep with providers and health plans, in constantly providing health information and wellness counseling that can prevent the high rates of morbidity and mortality in this pandemic, he said.

And, Curry added, that approach would be effective for other health initiatives, such as cancer screenings or diabetes care.

But the researchers expressed concern that the lessons from the pandemic, and the disparities revealed by their work, are not being heeded even now.

Rates of new vaccinations and boosters have slowed as Massachusetts has exited the winter surge and as officials now project a return to normal, said Bor, the studys lead author. Without new efforts to expand coverage, these inequities are likely to persist.

The upshot, he said, is that there are going to be a lot of people in poorer, lower-education ZIP codes regardless of racial composition who are going to suffer in future COVID waves because of low vaccination and booster rates.

Kay Lazar can be reached at kay.lazar@globe.com Follow her on Twitter @GlobeKayLazar.

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New COVID-19 vaccine study challenges stereotypes of who is getting the shots - The Boston Globe

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